Autoantibodies against the calcium-sensing receptor and cytokines in autoimmune polyglandular syndromes types 2, 3 and 4
| Autor: | Anthony P. Weetman, E. Helen Kemp, Julie A. Porter, Lara Frommer, George J. Kahaly |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Autoimmunity 030209 endocrinology & metabolism medicine.disease_cause Autoantigens Mitochondrial Proteins Parathyroid Glands 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine medicine Humans Polyendocrinopathies Autoimmune Receptor Aged Autoantibodies Subclinical infection business.industry Autoantibody Nuclear Proteins Middle Aged medicine.disease Anti-thyroid autoantibodies 030104 developmental biology Cytokine Autoimmune polyendocrine syndrome type 1 Case-Control Studies Immunology Cytokines Female Calcium-sensing receptor business Receptors Calcium-Sensing |
| Zdroj: | Clinical Endocrinology. 88:139-145 |
| ISSN: | 0300-0664 |
| Popis: | OBJECTIVE: The frequency of autoimmunity against the parathyroid glands in patients with polyglandular autoimmunity that is not due to autoimmune polyendocrine syndrome type 1 (APS1) is unclear. To investigate this, the current study aimed to determine the prevalence of autoantibodies against parathyroid autoantigens the calcium-sensing receptor (CaSR) and NACHT leucine-rich-repeat protein 5 (NALP5) in a large group of patients with non-APS1 polyendocrine autoimmunity. Possible occult APS1 was investigated by cytokine autoantibody measurement and AIRE gene analysis. DESIGN, SUBJECTS, AND MEASUREMENTS: Subjects were 178 patients with APS2, 3 or 4, and 80 healthy blood donors. Autoantibodies against the CaSR, NALP5, and cytokines were measured by immunoprecipitation, radioligand binding assays, or ELISA, respectively. RESULTS: Four patient samples (2.2%), but none of the controls, were positive for CaSR autoantibodies. NALP5 autoantibodies were not detected in any participant. Eleven patients (6.2%) had cytokine autoantibodies, but none of the control samples was positive. None of the patients with cytokine autoantibodies had any known or novel mutations in the AIRE gene. CONCLUSIONS: The low prevalence of CaSR autoantibodies indicate a very low level of subclinical parathyroid autoimmunity in APS types 2, 3 and 4. In addition, autoantibodies against cytokines constitute an uncommon feature of non-APS1 polyglandular autoimmunity. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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