Serum metabolic signatures of coronary and carotid atherosclerosis and subsequent cardiovascular disease
| Autor: | Xiuqing Guo, Russell P. Tracy, Kent D. Taylor, Ioanna Tzoulaki, David Mosen, John C. Lindon, Alireza Moayyeri, John C. Chambers, Christian Gieger, David M. Herrington, Timothy M. D. Ebbels, Jeremy K. Nicholson, Albert Hofman, Marc Chadeau-Hyam, Benjamin Lehne, Evangelos Evangelou, Paul Elliott, Abbas Dehghan, Claire L. Boulangé, Maryam Kavousi, Elaine Holmes, Ibrahim Karaman, Jaspal S. Kooner, Raphaële Castagné, Oscar H. Franco, Jerome I. Rotter, Marie Loh, Elena Chekmeneva, Manuja Kaluarachchi, Diana L. Santos Ferreira, Philip Greenland, Paul S. de Vries |
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| Přispěvatelé: | Epidemiology, Commission of the European Communities, Imperial College Healthcare NHS Trust- BRC Funding, National Institutes of Health, Health Data Research Uk, Medical Research Council (MRC) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Carotid Artery Diseases Cardiac & Cardiovascular Systems Prevention and Epidemiology Apolipoprotein B PREDICTION Proton Magnetic Resonance Spectroscopy Intima-media thickness Coronary Artery Disease Disease 030204 cardiovascular system & hematology medicine.disease_cause chemistry.chemical_compound 0302 clinical medicine WIDE ASSOCIATION Prospective Studies Myocardial infarction 610 Medicine & health 1102 Cardiorespiratory Medicine and Haematology Epidemiological studies 0303 health sciences SPECTROSCOPY biology OBJECTIVES RECOVERY Middle Aged Cardiovascular Diseases Female Cardiology and Cardiovascular Medicine Life Sciences & Biomedicine 360 Social problems & social services Adult medicine.medical_specialty Metabolic phenotyping BIOMARKERS Creatine Coronary artery calcium 03 medical and health sciences Metabolomics SDG 3 - Good Health and Well-being Clinical Research Internal medicine medicine Humans cardiovascular diseases Aged 030304 developmental biology Creatinine Science & Technology business.industry MORTALITY Research QUANTIFICATION Atherosclerosis medicine.disease Endocrinology MYOCARDIAL-INFARCTION Cardiovascular System & Hematology chemistry Cardiovascular System & Cardiology RISK-FACTORS Metabolic Phenotyping Coronary Artery Calcium Intima-media Thickness Epidemiological Studies biology.protein business Oxidative stress |
| Zdroj: | European Heart Journal, 40(34), 2883-+. Oxford University Press Eur. Heart J. 40, 2883-2896 (2019) European Heart Journal Tzoulaki, Ioanna; Castagné, Raphaële; Boulangé, Claire L; Karaman, Ibrahim; Chekmeneva, Elena; Evangelou, Evangelos; Ebbels, Timothy M D; Kaluarachchi, Manuja R; Chadeau-Hyam, Marc; Mosen, David; Dehghan, Abbas; Moayyeri, Alireza; Ferreira, Diana L Santos; Guo, Xiuqing; Rotter, Jerome I; Taylor, Kent D; Kavousi, Maryam; de Vries, Paul S; Lehne, Benjamin; Loh, Marie; ... (2019). Serum metabolic signatures of coronary and carotid atherosclerosis and subsequent cardiovascular disease. European Heart Journal, 40(34), pp. 2883-2896. Oxford University Press 10.1093/eurheartj/ehz235 |
| ISSN: | 0195-668X |
| DOI: | 10.7892/boris.130757 |
| Popis: | Aims To characterize serum metabolic signatures associated with atherosclerosis in the coronary or carotid arteries and subsequently their association with incident cardiovascular disease (CVD). Methods and results We used untargeted one-dimensional (1D) serum metabolic profiling by proton nuclear magnetic resonance spectroscopy (1H NMR) among 3867 participants from the Multi-Ethnic Study of Atherosclerosis (MESA), with replication among 3569 participants from the Rotterdam and LOLIPOP studies. Atherosclerosis was assessed by coronary artery calcium (CAC) and carotid intima-media thickness (IMT). We used multivariable linear regression to evaluate associations between NMR features and atherosclerosis accounting for multiplicity of comparisons. We then examined associations between metabolites associated with atherosclerosis and incident CVD available in MESA and Rotterdam and explored molecular networks through bioinformatics analyses. Overall, 30 1H NMR measured metabolites were associated with CAC and/or IMT, P = 1.3 × 10−14 to 1.0 × 10−6 (discovery) and P = 5.6 × 10−10 to 1.1 × 10−2 (replication). These associations were substantially attenuated after adjustment for conventional cardiovascular risk factors. Metabolites associated with atherosclerosis revealed disturbances in lipid and carbohydrate metabolism, branched chain, and aromatic amino acid metabolism, as well as oxidative stress and inflammatory pathways. Analyses of incident CVD events showed inverse associations with creatine, creatinine, and phenylalanine, and direct associations with mannose, acetaminophen-glucuronide, and lactate as well as apolipoprotein B (P Conclusion Metabolites associated with atherosclerosis were largely consistent between the two vascular beds (coronary and carotid arteries) and predominantly tag pathways that overlap with the known cardiovascular risk factors. We present an integrated systems network that highlights a series of inter-connected pathways underlying atherosclerosis. |
| Databáze: | OpenAIRE |
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