A Crucial Role for Diet in the Relationship Between Gut Microbiota and Cardiometabolic Disease
| Autor: | Sara-Joan Pinto-Sietsma, Ilias Attaye, Hilde Herrema, Max Nieuwdorp |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Mediterranean diet High animal Human metabolism Physiology 030209 endocrinology & metabolism Context (language use) Disease Biology Gut flora Diet Mediterranean Risk Assessment digestive system General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Prevalence Humans cardiometabolic disease gut microbiota Diet Vegetarian Role Type 2 Diabetes Mellitus General Medicine Prognosis Cardiometabolic disease biology.organism_classification Gastrointestinal Microbiome 030104 developmental biology Diabetes Mellitus Type 2 Cardiovascular Diseases Female dietary pattern diet |
| Zdroj: | Annual Review of Medicine. 71:149-161 |
| ISSN: | 1545-326X 0066-4219 |
| DOI: | 10.1146/annurev-med-062218-023720 |
| Popis: | Cardiometabolic disease (CMD), such as type 2 diabetes mellitus and cardiovascular disease, contributes significantly to morbidity and mortality on a global scale. The gut microbiota has emerged as a potential target to beneficially modulate CMD risk, possibly via dietary interventions. Dietary interventions have been shown to considerably alter gut microbiota composition and function. Moreover, several diet-derived microbial metabolites are able to modulate human metabolism and thereby alter CMD risk. Dietary interventions that affect gut microbiota composition and function are therefore a promising, novel, and cost-efficient method to reduce CMD risk. Studies suggest that fermentable carbohydrates can beneficially alter gut microbiota composition and function, whereas high animal protein and high fat intake negatively impact gut microbiota function and composition. This review focuses on the role of macronutrients (i.e., carbohydrate, protein, and fat) and dietary patterns (e.g., vegetarian/vegan and Mediterranean diet) in gut microbiota composition and function in the context of CMD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|