Factors Affecting Selenium Status in Infants on Parenteral Nutrition Therapy
| Autor: | Timothy Sentongo, Anita Rao, Dana Weinstein, Taylor Hebert, Hilary Jericho, Cecelia Pompeii-Wolfe, Kristen Wroblewski, Tiffany Patton, Sudhir Sriram |
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| Rok vydání: | 2021 |
| Předmět: |
Parenteral Nutrition
medicine.medical_specialty chemistry.chemical_element Gastroenterology Selenium Enteral Nutrition Selenium deficiency Internal medicine medicine Humans Infant Very Low Birth Weight Hypoalbuminemia Child Retrospective Studies business.industry Infant Newborn Infant Gestational age Retrospective cohort study Odds ratio medicine.disease Micronutrient Parenteral nutrition chemistry Infant Extremely Low Birth Weight Child Preschool Pediatrics Perinatology and Child Health business |
| Zdroj: | Journal of Pediatric Gastroenterology & Nutrition. 73:e73-e78 |
| ISSN: | 1536-4801 0277-2116 |
| DOI: | 10.1097/mpg.0000000000003174 |
| Popis: | INTRODUCTION Selenium is an essential micronutrient that must be supplemented in infants and young children on exclusive parenteral nutrition (PN). We examined selenium status and clinical factors associated with a deficiency in infants on PN. METHODS This was a retrospective cohort study of pediatric patients receiving PN with routine monitoring of selenium status. Deficiency was diagnosed using age-based norms of plasma selenium status. Associations between selenium deficiency and the following clinical factors were examined: birthweight status: extremely low birthweight (ELBW) versus very low birthweight (VLBW) versus low birthweight (LBW) versus normal birthweight (NBW), serum albumin status, presence of cholestasis, and co-administration of enteral feeds. RESULTS A total of 42 infants were included with gestational age [median (interquartile range)] 28 weeks (25,34). The prevalence of selenium deficiency was 80% and the prevalence of albumin deficiency was 87.5%. The odds of selenium deficiency were higher in ELBW infants (odds ratio = 17.84, 95% confidence interval [4.04-78.72], P |
| Databáze: | OpenAIRE |
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