Vascular endothelial growth factor: the link between cardiovascular risk factors and microalbuminuria?
| Autor: | van Dirk Veldhuisen, van Wiekert Gilst, Folkert W. Asselbergs, Gilles F. H. Diercks, RA Tio, de Rudolf Boer, Bas Langeveld, de Paul Jong |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A medicine.medical_specialty Population Vascular permeability Cohort Studies chemistry.chemical_compound Electrocardiography Risk Factors Internal medicine medicine Albuminuria Humans Risk factor education education.field_of_study Proteinuria business.industry Vascular disease Odds ratio Middle Aged medicine.disease Vascular endothelial growth factor Endocrinology Logistic Models chemistry Cardiovascular Diseases Case-Control Studies Microalbuminuria Female medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | International journal of cardiology. 93(2-3) |
| ISSN: | 0167-5273 |
| Popis: | Background: Microalbuminuria, i.e. slightly elevated urinary albumin excretion, is associated with increased cardiovascular risk factors and cardiovascular morbidity in the general population. Microalbuminuria has been proposed to indicate increased endothelial permeability. Unknown are the mechanisms underlying this increased vascular permeability. Vascular endothelial growth factor (VEGF), also known as vascular permeability factor, increases endothelial permeability. We hypothesised that plasma VEGF levels may be associated with microalbuminuria in a large sample of the general population. Methods: Out of a large sample of the general population, we studied 189 control subjects (urinary albumin excretion (UAE): 0–30 mg/24 h) and 194 microalbuminuric subjects (UAE: 30–300 mg/24 h), matched for age, sex and the presence of ischemia on the electrocardiogram. Results: Subjects with microalbuminuria had significant higher plasma levels of VEGF (p |
| Databáze: | OpenAIRE |
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