Additional insulin dosing for fat and protein in children with type 1 diabetes using multiple daily injections

Autor:	Anne Marie Frohock, Jason Oke, Chandan Yaliwal, Julie Edge, Rachel E. J. Besser
Rok vydání:	2022
Předmět:	Blood Glucose Adolescent Blood Glucose Self-Monitoring Endocrinology Diabetes and Metabolism Postprandial Period Hypoglycemia Diabetes Mellitus Type 1 Insulin Infusion Systems Pediatrics Perinatology and Child Health Internal Medicine Humans Hypoglycemic Agents Insulin Child Meals
Zdroj:	Pediatric Diabetes. 23:742-748
ISSN:	1399-5448 1399-543X
Popis:	High-fat high-protein (HFHP) meals are associated with post-prandial hyperglycemia in type 1 diabetes (T1D), administration of additional insulin for such meals is recommended in order to optimize glucose levels. Optimal timing of additional insulin for HFHP meals in children and young people receiving multiple daily injections (MDI) remains unclear.To investigate the glycemic impact of additional insulin doses given before or after eating a HFHP meal in children with T1D using MDI.A randomized, controlled three period crossover trial of 27 participants aged 13 years (6.1-17.7) at two Pediatric Diabetes centers was conducted. Additional rapid-acting insulin for the fat-protein content of a standardized HFHP meal was given at three time pointsThere was no difference in post-prandial glucose parameters when additional HFHP insulin was administered atWe found no benefit in giving additional insulin as a split dose for HFHP meals in children using MDI, mild hypoglycemia was common. Future studies would benefit from refinement of the insulin dose algorithm.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d72ad5d9cb2468edc9f172c5a185c09f https://doi.org/10.1111/pedi.13372 Zobrazit plný text záznamu