Study of Sr–Ca–Si-based scaffolds for bone regeneration in osteoporotic models
| Autor: | Qianju Wu, Jin Wen, Xinquan Jiang, Fei Jiang, Ziyuan Zhu, Xiao Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Scaffold
Bone Regeneration Osteoporosis Diseases 02 engineering and technology Article 03 medical and health sciences 0302 clinical medicine Osteogenesis medicine Regeneration Animals Humans Bone regeneration General Dentistry Congenital diseases Tissue Engineering Tissue Scaffolds business.industry Regeneration (biology) Mesenchymal stem cell Mesenchymal Stem Cells 030206 dentistry 021001 nanoscience & nanotechnology medicine.disease lcsh:RK1-715 medicine.anatomical_structure Strontium lcsh:Dentistry Osteoporotic bone Cancer research 0210 nano-technology business Blood vessel |
| Zdroj: | International Journal of Oral Science, Vol 12, Iss 1, Pp 1-6 (2020) International Journal of Oral Science |
| ISSN: | 2049-3169 1674-2818 |
| Popis: | Bone tissue engineering has emerged as a promising alternative therapy for patients who suffer bone fractures or defects caused by trauma, congenital diseases or tumours. However, the reconstruction of bone defects combined with osteoporosis remains a great challenge for clinicians and researchers. Based on our previous study, Ca–Si-based bioceramics (MSCs) showed enhanced bone formation capabilities under normal conditions, and strontium was demonstrated to be therapeutic in promoting bone quality in osteoporosis patients. Therefore, in the present study, we attempted to enlarge the application range of MSCs with Sr incorporation in an osteoporotic bone regeneration model to evaluate whether Sr could assist in regeneration outcomes. In vitro readout suggested that Sr-incorporated MSC scaffolds could enhance the expression level of osteogenic and angiogenic markers of osteoporotic bone mesenchymal stem cells (OVX BMSCs). Animal experiments showed a larger new bone area; in particular, there was a tendency for blood vessel formation to be enhanced in the Sr-MSC scaffold group, showing its positive osteogenic capacity in bone regeneration. This study systematically illustrated the effective delivery of a low-cost therapeutic Sr agent in an osteoporotic model and provided new insight into the treatment of bone defects in osteoporosis patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|