Effects of Aerobic Exercise on Systemic Insulin Degludec Concentrations in People With Type 1 Diabetes
| Autor: | David Herzig, Christos T. Nakas, Gemma Reverter-Branchat, Lia Bally, Christoph Stettler, Mario Álvarez-Martínez, Michael Groessl, Christophe Kosinski |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Blood Glucose Insulin degludec medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Biomedical Engineering Insulin Glargine 610 Medicine & health Bioengineering Young Adult Internal medicine Internal Medicine medicine Humans Hypoglycemic Agents Aerobic exercise Prospective Studies Exercise Glycated Hemoglobin Type 1 diabetes business.industry Insulin Original Articles medicine.disease Diabetes Mellitus Type 1 Endocrinology business |
| Zdroj: | Herzig, David; Groessl, Michael; Álvarez-Martínez, Mario; Reverter-Branchat, Gemma; Nakas, Christos T.; Kosinski, Christophe; Stettler, Christoph; Bally, Lia (2021). Effects of Aerobic Exercise on Systemic Insulin Degludec Concentrations in People With Type 1 Diabetes. Journal of diabetes science and technology, 17(1), pp. 172-175. Sage 10.1177/19322968211043915 J Diabetes Sci Technol |
| DOI: | 10.48350/164272 |
| Popis: | Background: There is conflicting evidence on the effect of exercise on systemic insulin concentrations in adults with type 1 diabetes. Methods: This prospective single-arm study examined the effect of exercise on systemic insulin degludec (IDeg) concentrations. The study involved 15 male adults with type 1 diabetes (age 30.7 ± 8.0 years, HbA1c 6.9 ± 0.7%) on stable IDeg regimen. Blood samples were collected every 15 minutes at rest, during 60 minutes of cycling (66% VO2max) and until 90 minutes after exercise termination. IDeg concentrations were quantified using high-resolution mass-spectrometry and analyzed applying generalized estimation equations. Results: Compared to baseline, systemic IDeg increased during exercise over time ( P Conclusions: A single bout of aerobic exercise increases systemic IDeg exposure in adults on a stable basal IDeg regimen. This finding may have important implications for future hypoglycemia mitigation strategies around physical exercise in IDeg-treated patients. |
| Databáze: | OpenAIRE |
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