Unraveling predictors affecting compliance to MRI in Parkinson's disease
| Autor: | Mariangela Pierantozzi, Francesca Assogna, Francesco E. Pontieri, Tommaso Gili, Patrizia Paravia, Gianfranco Spalletta, Fabrizio Piras, Claudia Cacciari, Luca Cravello, Alessandro Stefani, Clelia Pellicano, Carlo Caltagirone, Mariangela Iorio |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Parkinson's disease Disease Anxiety Logistic regression Severity of Illness Index Antiparkinson Agents symbols.namesake Cognition Internal medicine medicine Humans Aged Univariate analysis medicine.diagnostic_test Neuropsychology Parkinson Disease Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging Bonferroni correction Neurology symbols Physical therapy Patient Compliance Female Settore MED/26 - Neurologia Neurology (clinical) Geriatrics and Gerontology medicine.symptom MRI Psychology |
| Zdroj: | Parkinsonism & Related Disorders. 21:964-967 |
| ISSN: | 1353-8020 |
| DOI: | 10.1016/j.parkreldis.2015.05.009 |
| Popis: | Introduction Magnetic resonance imaging (MRI) is a sensitive, noninvasive and widely available technique for studying Parkinson's disease (PD) from both research and clinical perspective. Several issues may physically impede execution of MRI. Moreover, the severity of motor or non-motor symptoms of PD might reduce compliance to MRI. Here we investigated predictors affecting compliance to MRI in PD patients. Methods Two-hundred-thirty-six PD patients underwent clinical, neuropsychological and neuropsychiatric investigations. Accordingly to their ability/inability to perform MRI scan, they were divided into 3 groups. Forty-two patients had physical incompatibility to MRI (PI); 51 patients refused to undergo scan during the MRI evaluation session (RR); 143 patients accepted to undergo and successfully completed MRI (SP). Multivariate/Univariate Analyses of Variance, followed by Bonferroni's post-hoc comparisons, were used to assess differences among groups. To identify predictors of compliance to MRI scan in the whole PD sample (SP vs. RR + PI) we carried out a logistic regression analysis. Results PI subjects were significantly older, had higher UPRDRS-III score, received lower daily dopamine agonist doses, and displayed worse cognitive performances than SP. RR subjects had significantly higher anxiety severity than SP. Lower daily dopamine agonist equivalents and higher anxiety scores were the significant whole predictors of not compliance to MRI in the logistic regression analysis. Conclusions These results show that demographic, neuropsychological and neuropsychiatric features may limit compliance to MRI in PD, and provide valuable aid for setting and interpreting research and clinical MRI studies in PD. |
| Databáze: | OpenAIRE |
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