Prognostic value of a three-grade classification in primary epithelial parotid carcinoma: Result of a histological review from a 20-year experience of total parotidectomy with neck dissection in a single institution
| Autor: | Jacques Yachouh, Louis Crampette, Elham Jouzdani, Jean-Luc Faillie, Marc Makeieff, G. Pierre, Renaud Garrel, V. Burcia, Valérie Costes, Flora Poizat, Bernard Guerrier, C. Cartier |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent medicine.medical_treatment Young Adult medicine Carcinoma Humans Parotid Gland Stage (cooking) Intermediate Grade Child Lymph node Aged Neoplasm Staging Retrospective Studies Aged 80 and over Postoperative Care Univariate analysis business.industry Neck dissection Middle Aged medicine.disease Facial nerve Parotid Neoplasms Surgery Dissection Treatment Outcome medicine.anatomical_structure Oncology Lymphatic Metastasis Neck Dissection Female Radiotherapy Adjuvant business |
| Zdroj: | European Journal of Cancer. 46:323-331 |
| ISSN: | 0959-8049 |
| DOI: | 10.1016/j.ejca.2009.10.012 |
| Popis: | Background The tumour grading of primary parotid cancers (PPCs) remains controversial. Methods A 20-year standardised single centre treatment has been assessed retrospectively. The histological review of 155 consecutively treated parotid malignancies identified 96 suitable cases for univariate and multivariate survival analyses. Results Treatment involved total parotidectomy, neck dissection and post-operative radiotherapy in, respectively, 91.7%, 83.3% and 70.4% of cases. The 5-year overall survival, disease-specific and recurrence-free survival rates were 79.4%, 83.5% and 70.8%, respectively. Univariate analysis confirmed the classical prognostic factors, i.e. age > 60 years, male gender, facial palsy, hardness of the tumour, clinical stage, tumour grade, facial nerve invasion and lymph node metastases. Multivariate analysis identified a three-grade classification just after the clinical stage as the most important prognostic factor. Conclusion This study identifies the prognostic significance of intermediate grade tumours. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect