Prognostic value of elevated high-sensitivity cardiac troponin T in patients admitted to an emergency department with atrial fibrillation
| Autor: | Evangelos Giannitsis, Matthias Mueller-Hennessen, Hugo A. Katus, Mehrshad Vafaie, Moritz Biener, Katharina Arens, Kiril M. Stoyanov |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty 030204 cardiovascular system & hematology Risk Assessment 03 medical and health sciences Patient Admission 0302 clinical medicine Troponin T Predictive Value of Tests Risk Factors Physiology (medical) Internal medicine Atrial Fibrillation Risk of mortality Humans Medicine 030212 general & internal medicine Myocardial infarction Aged Retrospective Studies Aged 80 and over business.industry Proportional hazards model Hazard ratio Retrospective cohort study Atrial fibrillation Emergency department Middle Aged Prognosis medicine.disease Up-Regulation Predictive value of tests Cardiology Female Emergency Service Hospital Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | EP Europace. 20:582-588 |
| ISSN: | 1532-2092 1099-5129 |
| DOI: | 10.1093/europace/eux063 |
| Popis: | Aims Elevated levels of high-sensitivity cardiac troponin T (hsTnT) indicate underlying heart disease and are known to predict adverse outcomes in various patient populations. Their role in atrial fibrillation (AF) is still under debate. Methods and results This retrospective study included 2898 consecutive patients presenting with AF to the emergency department of the Department of Cardiology, Heidelberg University Hospital. Multivariable Cox regression was used to assess associations between hsTnT and mortality. Elevated hsTnT levels were associated with increased risk of all-cause mortality in all patients with AF, as well as in each subtype of AF. After adjustment for multiple risk factors, both detectable hsTnT below the 99th percentile (5-14 ng/L, adjusted hazard ratio (HR): 4.86 [95% CI: 1.77-13.34], P = 0.002) and elevated hsTnT (>14 ng/L, adjusted HR: 13.42 [95% CI: 4.95-36.40], P |
| Databáze: | OpenAIRE |
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