High Prevalence of Skin Reactions Among Pediatric Patients with Type 1 Diabetes Using New Technologies: The Alarming Role of Colophonium
| Autor: | Mauro Iannelli, Stefano Passanisi, Giovanni Battista Pajno, Lucia Caminiti, Maria Francesca Messina, Andrea Barbalace, Alessandra Marino, Fortunato Lombardo, Giuseppina Salzano |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Allergy medicine.medical_specialty Side effect Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Continuous subcutaneous insulin infusion 030209 endocrinology & metabolism Patch test Sensitization 03 medical and health sciences Wearable Electronic Devices 0302 clinical medicine Endocrinology Diabetes mellitus Adhesives medicine Prevalence Humans 030212 general & internal medicine Child Allergic contact dermatitis Colophonium Retrospective Studies Type 1 diabetes business.industry Insulin medicine.disease Dermatology Skin reactions Medical Laboratory Technology Skin reaction Diabetes Mellitus Type 1 Italy Dermatitis Allergic Contact Female business Resins Plant |
| Zdroj: | Diabetes technologytherapeutics. 22(1) |
| ISSN: | 1557-8593 |
| Popis: | In the past few years, the increasing use of devices for diabetes treatment, such as continuous subcutaneous insulin infusion pumps, flash glucose monitoring, continuous glucose monitoring systems, sensor-augmented pumps, and automated insulin delivery devices, has resulted in important improvements in disease management. Meanwhile, the longer a patient uses a device, the greater the likelihood of developing a skin reaction. Allergic contact dermatitis is the most frequently described skin side effect caused by adhesive tapes contained in the insulin infusion sets or glucose sensor sets and used to connect these devices to the body. We describe 18 patients, followed up at our Pediatric Diabetes Centre, who experienced dermatological complications due to diabetes device use from January 2018 to December 2018. All the patients were patch tested with allergens from a "standard" series and from a "plastics and glues" series. Patch tests resulted positive in 66.7% of patients. Colophonium was the most frequently isolated sensitizing allergen (41.1% of cases). It is a complex mixture of >100 compounds derived from pine trees. Colophonium is commonly used, in both unmodified and modified forms, as a fast-acting adhesive for industrial, medical, or other commercial uses. Its presence in the adhesive of the insulin sets and glucose sensors was confirmed by the manufacturer of some devices brand. On the basis of our results, we stress the importance of contacting manufacturers for product information. We also highlight that there should be stricter legal restrictions to label medical adhesives, even if only small amounts of colophonium are used. |
| Databáze: | OpenAIRE |
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