Randomised study of intra-oral kinetics of fluoride-containing toothpastes
| Autor: | Luke Davies, Charles R. Parkinson, Gavin Vaughan Thomas, David Payne, Gary R. Burnett |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Toothbrushing
business.product_category Cocamidopropyl betaine Excipient 03 medical and health sciences chemistry.chemical_compound Fluorides 0302 clinical medicine medicine Dentifrice Humans 030212 general & internal medicine General Dentistry Orange juice Toothpaste Chromatography Cross-Over Studies Chemistry 030206 dentistry Crossover study Kinetics Sodium Fluoride Tetrasodium pyrophosphate business Fluoride Toothpastes medicine.drug |
| Zdroj: | Journal of dentistry. 106 |
| ISSN: | 1879-176X |
| Popis: | This randomised, controlled, analyst blind, crossover study aimed to evaluate and compare salivary fluoride and calcium ion concentration over 60 min following brushing with an assigned treatment and following an orange juice (OJ) or deionised (DI) water rinse 60 min post-brushing.Study treatments, both containing 1150 ppm fluoride as NaF and 5% w/w KNOA sharp increase in salivary fluoride ion concentration immediately post-brushing with either toothpaste decreased over time. Fluoride concentration following Test toothpaste use was numerically higher than the Comparator at all timepoints, with a significant difference from 10 min post-brushing (p.05). Following the 60 min rinse, there were no significant differences between the Test or Comparator + OJ groups in salivary fluoride concentration but the Test + DI water group was significantly lower than Test (p.001) or Comparator (p.001) + OJ groups. A reduction in salivary calcium ion concentration was seen immediately post-brushing and after the OJ rinse with both toothpastes. Significant differences were observed in favour of the Test toothpaste at all timepoints (p.05) and for Test and Comparator + OJ group (p.001) compared with Test + DI water rinse. Both treatments were generally well-tolerated.This study demonstrated that toothpaste formulations with identical declared fluoride concentrations and the same fluoride source give rise to differing intraoral fluoride concentrations over time, which are potentially related to different formulation excipient effects.By understanding the interaction of toothpaste formulation excipients in the oral environment, formulations can be developed that maximise retention of fluoride in the oral environment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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