Effects on Spatial Cognition and Nociceptive Behavior Following Peripheral Nerve Injury in Rats with Lesion of the Striatal Marginal Division Induced by Kainic Acid
| Autor: | Chang Zhou, Guoying Li, Sumin Tian, Yinghong Tian, Li Yan, Jing Liu, Yuyun Jiang, Yuxin Ma |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Nociception Kainic acid medicine.medical_specialty Pain Morris water navigation task Substance P Biochemistry Rats Sprague-Dawley Lesion Cellular and Molecular Neuroscience chemistry.chemical_compound Peripheral Nerve Injuries Spinal Cord Dorsal Horn Internal medicine Animals Medicine Maze Learning Kainic Acid Behavior Animal business.industry General Medicine Nerve injury Corpus Striatum Rats nervous system diseases Posterior Horn Cells Endocrinology chemistry Space Perception Anesthesia Peripheral nerve injury Neuropathic pain Inflammation Mediators medicine.symptom business Excitatory Amino Acid Antagonists psychological phenomena and processes |
| Zdroj: | Neurochemical Research. 40:2357-2364 |
| ISSN: | 1573-6903 0364-3190 |
| DOI: | 10.1007/s11064-015-1727-6 |
| Popis: | Neuropathic pain and cognitive deficit are frequently comorbidity in clinical, but their underlying correlation and mechanisms remain unclear. Here, we utilized a combined rat model including kainic acid (KA) injection into bilateral striatal marginal division and chronic constriction nerve injury (CCI). PET/CT scans revealed that the SUVmax of KA rats was significantly decreased when compared to naive and saline rats. In contrast to the naive and saline rats, KA rats had longer latencies in locating the hidden platform on day 4, 5 in Morris water maze task. Thermal hyperalgesia and mechanical allodynia of KA rats were alleviated following CCI. Immunostaining results showed that substance P was markedly increased within ipsilateral spinal cord dorsal horn of KA rats after CCI, especially on the post-operative day 14. By means of real-time PCR, the up-regulation of GluR within ipsilateral spinal cord dorsal horn was observed in all KA and CCI rats. PKCγ, IL-6 and NF-κB were up-regulated in both CCI rats when compared to naive and their respective sham rats. These results suggest that cognitive impairment of rats altered the pain behaviors, and these intracellular regulators play crucial roles in the process of neuropathic pain. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink