Reduced intracellular accumulation of azole antifungal results in resistance in Candida albicans isolate NCPF 3363
| Autor: | Steven L. Kelly, David C. Lamb, Nigel J. Manning, Diane E. Kelly |
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| Rok vydání: | 2006 |
| Předmět: |
Drug
Antifungal Agents media_common.quotation_subject Microbial Sensitivity Tests Biology Microbiology Candida albicans Genetics medicine Chronic mucocutaneous candidiasis Fluconazole Molecular Biology media_common chemistry.chemical_classification Membrane transport protein Candidiasis Chronic Mucocutaneous Drug Resistance Microbial Transporter medicine.disease biology.organism_classification Multiple drug resistance Sterols Ketoconazole chemistry biology.protein Azole Intracellular |
| Zdroj: | FEMS Microbiology Letters. 147:189-193 |
| ISSN: | 0378-1097 |
| Popis: | Candida albicans strain NCPF 3363 was isolated from a British patient with chronic mucocutaneous candidiasis (CMC) and confirmed to be resistant to azole antifungal compounds. In this study we investigate the molecular basis of resistance and show that azole tolerance in NCPF 3363 was associated with reduced intracellular accumulation of drug and not reduced affinity for the target site, as previously indicated. Relative impermeability or the presence of transporters related to those responsible for multidrug resistance are implicated in the mechanism of resistance. |
| Databáze: | OpenAIRE |
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