A Maternal Serum Metabolite Ratio Predicts Large for Gestational Age Infants at Term: A Prospective Cohort Study
| Autor: | Ulla Sovio, Neil Goulding, Nancy McBride, Emma Cook, Francesca Gaccioli, D Stephen Charnock-Jones, Deborah A Lawlor, Gordon C S Smith |
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| Přispěvatelé: | Sovio, Ulla [0000-0002-0799-1105], Goulding, Neil [0000-0002-2488-4598], McBride, Nancy [0000-0003-4439-4710], Cook, Emma [0000-0002-6142-4443], Gaccioli, Francesca [0000-0001-7178-8921], Charnock-Jones, D Stephen [0000-0002-2936-4890], Lawlor, Deborah A [0000-0002-6793-2262], Smith, Gordon CS [0000-0003-2124-0997], Apollo - University of Cambridge Repository |
| Rok vydání: | 2021 |
| Předmět: |
Endocrinology
Diabetes and Metabolism Clinical Biochemistry Gestational Age large for gestational age Biochemistry Fetal Macrosomia Cohort Studies 03 medical and health sciences 0302 clinical medicine Endocrinology Pregnancy Birth Weight Humans macrosomia Prospective Studies 030212 general & internal medicine 030304 developmental biology 0303 health sciences Fetal Growth Retardation Biochemistry (medical) Infant Newborn Pregnancy Outcome prediction metabolomics 3. Good health Female pregnancy |
| Zdroj: | Sovio, U, Goulding, N J, Mcbride, N S, Cook, E, Gaccioli, F, Charnock-Jones, D S, Lawlor, D A & Smith, G 2021, ' A Maternal Serum Metabolite Ratio Predicts Large for Gestational Age Infants at Term : A Prospective Cohort Study ', Journal of Clinical Endocrinology and Metabolism, pp. 1-10 . https://doi.org/10.1210/clinem/dgab842 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/clinem/dgab842 |
| Popis: | Context Excessive birth weight is associated with maternal and neonatal complications. However, ultrasonically estimated large for gestational age (LGA; >90th percentile) predicts these complications poorly. Objective To determine whether a maternal serum metabolite ratio developed for fetal growth restriction (FGR) is predictive of birth weight across the whole range, including LGA at birth. Methods Metabolites were measured using ultrahigh performance liquid chromatography-tandem mass spectroscopy. The 4-metabolite ratio was previously derived from an analysis of FGR cases and a random subcohort from the Pregnancy Outcome Prediction study. Here, we evaluated its relationship at 36 weeks of gestational age (wkGA) with birth weight in the subcohort (n = 281). External validation in the Born in Bradford (BiB) study (n = 2366) used the metabolite ratio at 24 to 28 wkGA. Results The inverse of the metabolite ratio at 36 wkGA predicted LGA at term [the area under the receiver operating characteristic curve (AUROCC) = 0.82, 95% CI 0.73 to 0.91, P = 6.7 × 10−5]. The ratio was also inversely associated with birth weight z score (linear regression, beta = −0.29 SD, P = 2.1 × 10−8). Analysis in the BiB cohort confirmed that the ratio at 24 to 28 wkGA predicted LGA (AUROCC = 0.60, 95% CI 0.54 to 0.67, P = 8.6 × 10−5) and was inversely associated with birth weight z score (beta = −0.12 SD, P = 1.3 × 10−9). Conclusions A metabolite ratio which is strongly predictive of FGR is equally predictive of LGA birth weight and is inversely associated with birth weight across the whole range. |
| Databáze: | OpenAIRE |
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