Ghrelin: A Link between Eating Disorders, Obesity and Reproduction
Autor: | S. Destefanis, C. Gottero, C. Gauna, A. J. van der Lely, Fabio Broglio, Andrea Benso, Flavia Prodam, S. Bellone, Ezio Ghigo, Emanuela Arvat |
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Rok vydání: | 2004 |
Předmět: |
Male
medicine.medical_specialty Peptide Hormones media_common.quotation_subject Medicine (miscellaneous) Anorexia nervosa Feeding and Eating Disorders Eating Adrenocorticotropic Hormone Internal medicine Orexigenic medicine Animals Humans Endocrine system Obesity Receptor media_common Nutrition and Dietetics Human Growth Hormone business.industry Reproduction General Neuroscience digestive oral and skin physiology Appetite General Medicine Hydrogen-Ion Concentration Luteinizing Hormone medicine.disease Ghrelin Hormones Prolactin Eating disorders Endocrinology Female Energy Metabolism business hormones hormone substitutes and hormone antagonists Ghrelin secretion medicine.drug |
Zdroj: | Nutritional Neuroscience. 7:255-270 |
ISSN: | 1476-8305 1028-415X |
Popis: | Ghrelin, a 28-amino acid acylated peptide predominantly produced by the stomach, displays strong GH-releasing activity mediated by the hypothalamic-pituitary GH secretagogues (GHS) receptors (GHS-R) which had been shown specific for a family of synthetic, orally active molecules known as GHS. However, ghrelin and GHS, acting on central and peripheral receptors, also exert other actions. These include influence on pituitary functions, orexigenic action, influence on exocrine and endocrine gastro-entero-pancreatic functions, cardiovascular and anti-proliferative effects. In particular, the effect of ghrelin in promoting food intake and modulating energy metabolism strongly suggested that ghrelin has a key role in managing the neuroendocrine and metabolic response to starvation and that could be involved in the pathogenesis and/or in the metabolic and neuro-hormonal alterations of obesity and eating disorders. Although specific alterations in ghrelin secretion and/or action in obesity and anorexia nervosa (AN) have already been reported, the possibility that ghrelin analogues acting as agonists or antagonists has clinical perspectives for treatment of eating disorders presently remains a dream. |
Databáze: | OpenAIRE |
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