Antiinflammatory property of 3-aryl-5-(n-propyl)-1,2,4-oxadiazoles and antimicrobial property of 3-aryl-5-(n-propyl)-4,5-dihydro-1,2,4-oxadiazoles: their syntheses and spectroscopic studies
| Autor: | Rajendra M. Srivastava, Maria Tereza Jansen de A. Catanho, Marcelo J da Costa Silva, Osnir S. Viana, Analice Lima, José Otamar Falcão de Morais |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Staphylococcus aureus
Clinical Biochemistry Mycobacterium smegmatis Pharmaceutical Science Microbial Sensitivity Tests Saccharomyces cerevisiae Biochemistry Chemical synthesis chemistry.chemical_compound Mice Anti-Infective Agents Drug Discovery Candida albicans Escherichia coli Organic chemistry Animals Edema Butyraldehyde Molecular Biology Antibacterial agent Oxadiazoles biology Aspirin Aryl Spectrum Analysis Organic Chemistry Anti-Inflammatory Agents Non-Steroidal Enterobacter aerogenes biology.organism_classification Antimicrobial chemistry Sodium hypochlorite Molecular Medicine Bacillus subtilis |
| Zdroj: | Bioorganicmedicinal chemistry. 11(8) |
| ISSN: | 0968-0896 |
| Popis: | The synthesis of six 3-aryl-5-(n-propyl)-4,5dihydro-1,2,4-oxadiazoles 3a-f has been achieved in a facile manner by the reaction of an appropriate arylamidoxime 1a-f with butyraldehyde 2. Oxidation of 3a-f individually using MnO(2) in CH(2)Cl(2) or sodium hypochlorite in THF/H(2)O furnished 1,2,4-oxadiazoles 4a-f in good to excellent yields. Compounds 4a-f were also evaluated against inflammation. Except 4e, all of them reduced inflammation, however, 4c presented better antiinflammatory activity. A preliminary antimicrobial activity tests of 3a-f showed that these compounds possess activity against some microorganisms. In fact, 3c and 3f have been found to be more effective against Staphylococcus aureus, Mycobacterium smegmatis, and Candida albicans. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect