Ex vivo assessment and in vivo validation of non-invasive stent monitoring techniques based on microwave spectrometry
| Autor: | Juan M. O'Callaghan, Susana Amorós García de Valdecasas, Flavio David Gerez-Britos, Carolina Gálvez-Montón, Ferran Macià, Javier Tejada, Oriol Rodríguez-Leor, Carolina Soler-Botija, Gianluca Arauz-Garofalo, Antoni Bayes-Genis |
|---|---|
| Přispěvatelé: | Universitat Politècnica de Catalunya. Departament de Teoria del Senyal i Comunicacions, Universitat Politècnica de Catalunya. RF&MW - Grup de Recerca de sistemes, dispositius i materials de RF i microones |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_treatment
Cardiology lcsh:Medicine 030204 cardiovascular system & hematology Article 030218 nuclear medicine & medical imaging Cardiologia Pròtesis de Stent 03 medical and health sciences Mice 0302 clinical medicine In vivo Medicine Animals cardiovascular diseases Microwaves lcsh:Science Multidisciplinary Física::Física molecular::Espectroscòpia molecular [Àrees temàtiques de la UPC] business.industry Spectrum Analysis Non invasive lcsh:R Stent Espectroscòpia de microones medicine.disease equipment and supplies Microwave spectrometry Equipment Failure Analysis Stenosis Enginyeria biomèdica::Electrònica biomèdica::Electrònica en cardiologia [Àrees temàtiques de la UPC] surgical procedures operative Microwave spectroscopy Stents lcsh:Q business Nuclear medicine Stents (Surgery) Ex vivo |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona Recercat. Dipósit de la Recerca de Catalunya instname Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018) UPCommons. Portal del coneixement obert de la UPC Universitat Politècnica de Catalunya (UPC) Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Scientific Reports r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol |
| ISSN: | 2045-2322 |
| Popis: | Altres ajuts: Fundació La MARATÓ de TV3 (20153530/31), Unidad de Excelencia Maria de Maeztu (MDM2016-0600). This work has been developed in the context of AdvanceCat with the support of ACCIÓ (Catalonia Trade & Investment; Generalitat de Catalunya) Some conditions are well known to be directly associated with stent failure, including in-stent re-occlusion and stent fracture. Currently, identification of these high-risk conditions requires invasive and complex procedures. This study aims to assess microwave spectrometry (MWS) for monitoring stents non-invasively. Preliminary ex vivo data are presented to move to in vivo validation. Fifteen mice were assigned to receive subcutaneous stent implantations (n = 10) or sham operations (n = 5). MWS measurements were carried out at 0, 2, 4, 7, 14, 22, and 29 days of follow-up. Additionally, 5 stented animals were summited to micro-CT analyses at the same time points. At 29 days, 3 animals were included into a stent fracture subgroup and underwent a last MWS and micro-CT analysis. MWS was able to identify stent position and in-stent stenosis over time, also discerning significant differences from baseline measures (P < 0.001). Moreover, MWS identified fractured vs. non-fractured stents in vivo. Taken together, MWS emerges as a non-invasive, non-ionizing alternative for stent monitoring. MWS analysis clearly distinguished between in-stent stenosis and stent fracture phenomena. |
| Databáze: | OpenAIRE |
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