Citrus essential oils inhalation by mice: Behavioral testing, GCMS plasma analysis, corticosterone, and melatonin levels evaluation
| Autor: | Leire Virto Ruiz, Adriana Nunes Wolffenbüttel, Eliane Dallegrave, Bruna Tassi Borille, Viviane de Moura Linck, Ana I. Esquifino, Renata Pereira Limberger, Vanessa Rodrigues Coelho, Janaína Lucas de Oliveira Salomón, Mirna Bainy Leal, Maíra Kerpel dos Santos, Gabriela Curbeti Becker, Ana Claudia Fagundes, Pilar Cano, Kristiane de Cássia Mariotti, Amanda Zamboni |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Citrus medicine.drug_class Imipramine Gas Chromatography-Mass Spectrometry Melatonin 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Corticosterone Internal medicine Administration Inhalation medicine Oils Volatile Animals Plant Oils Pharmacology Inhalation Chemistry 030104 developmental biology Endocrinology Sedative Gas chromatography–mass spectrometry 030217 neurology & neurosurgery Citrus × sinensis medicine.drug Hormone |
| Zdroj: | Phytotherapy research : PTR. 32(1) |
| ISSN: | 1099-1573 |
| Popis: | The use of orange essential oils (EOs) as a complementary treatment is very common in Brazilian popular culture. The levels of melatonin (MEL) and corticosterone (CORT) hormones were investigated simultaneously, by the Luminex™ immunoassay system in mice plasma, after Citrus aurantium and Citrus sinensis EOs inhalation for 30 min. The plasma was analyzed by headspace through gas chromatography coupled to mass spectrometry for investigation of the EO components. Mice were submitted to behavioral testing to research anxiolytic-like, sedative, and antidepressant-like effects. The inhalation of atmosphere obtained from vaporization of 10% solution of this Citrus EO separately did not affect MEL or CORT plasma levels; that is, the MEL and CORT levels did not present variation in function of the EO in the schedule used. On the other hand, the imipramine positive control used altered the level of MEL as expected. The EO constituents were detected in plasma at different ratios that is present in inhaled EO. Behavioral tests showed that the inhalation of 10% C. sinensis EO presents an anxiolytic-like and sedative effect. Thus, C. sinensis EO can be a valuable tool for treatment of the anxiety disturbs, apparently without interference with MEL and CORT physiological levels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text