Dorsolateral neostriatum contribution to incentive salience: opioid or dopamine stimulation makes one reward cue more motivationally attractive than another
| Autor: | Alexandra G. DiFeliceantonio, Kent C. Berridge |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Conditioning Classical education Receptors Opioid mu Striatum Article Developmental psychology Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Reward Dopamine medicine Animals Amphetamine Motivation General Neuroscience technology industry and agriculture Enkephalin Ala(2)-MePhe(4)-Gly(5) Attraction Rats Analgesics Opioid Neostriatum DAMGO 030104 developmental biology chemistry Incentive salience Dopamine Agonists Female Cues μ-opioid receptor Indirect agonist Psychology Neuroscience psychological phenomena and processes 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | European Journal of Neuroscience. 43:1203-1218 |
| ISSN: | 0953-816X |
| DOI: | 10.1111/ejn.13220 |
| Popis: | Pavlovian cues for rewards can become attractive incentives: approached and 'wanted' as the rewards themselves. The motivational attractiveness of a previously learned cue is not fixed, but can be dynamically amplified during re-encounter by simultaneous activation of brain limbic circuitry. Here it was reported that opioid or dopamine microinjections in the dorsolateral quadrant of the neostriatum (DLS) of rats selectively amplify attraction toward a previously learned Pavlovian cue in an individualized fashion, at the expense of a competing cue. In an autoshaping (sign-tracking vs. goal-tracking) paradigm, microinjection of the mu opioid receptor agonist (DAMGO) or dopamine indirect agonist (amphetamine) in the DLS of sign-tracker individuals selectively enhanced their sign-tracking attraction toward the reward-predictive lever cue. By contrast, DAMGO or amphetamine in the DLS of goal-trackers selectively enhanced prepotent attraction toward the reward-proximal cue of sucrose dish. Amphetamine also enhanced goal-tracking in some sign-tracker individuals (if they ever defected to the dish even once). That DLS enhancement of cue attraction was due to stronger motivation, not stronger habits, was suggested by: (i) sign-trackers flexibly followed their cue to a new location when the lever was suddenly moved after DLS DAMGO microinjection; and (ii) DAMGO in the DLS also made sign-trackers work harder on a new instrumental nose-poke response required to earn presentations of their Pavlovian lever cue (instrumental conditioned reinforcement). Altogether, the current results suggest that DLS circuitry can enhance the incentive salience of a Pavlovian reward cue, selectively making that cue a stronger motivational magnet. |
| Databáze: | OpenAIRE |
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