Risk of gastrointestinal complications in breast cancer patients treated with neratinib: a meta-analysis
| Autor: | Hong-Feng Yan, Jingjing Lin, Ru-Yi Yan, Beining Zhang, Cheng-Lin Li, Nan Jiang, Xiang-wei Song, Zhan-yu Wang, Jin-Lian Zhou, Xiao Yan Fu, Yan Cui, Ao Li |
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| Rok vydání: | 2017 |
| Předmět: |
Diarrhea
Risk medicine.medical_specialty Gastrointestinal Diseases Vomiting Nausea Antineoplastic Agents Breast Neoplasms 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Humans Medicine Pharmacology (medical) 030212 general & internal medicine Adverse effect Gynecology business.industry Incidence (epidemiology) General Medicine medicine.disease 030220 oncology & carcinogenesis Relative risk Neratinib Quinolines Female medicine.symptom business medicine.drug |
| Zdroj: | Expert Opinion on Drug Safety. 16:1111-1119 |
| ISSN: | 1744-764X 1474-0338 |
| DOI: | 10.1080/14740338.2017.1354986 |
| Popis: | Backgrounds: Neratinib is a potent EGFR/HER2 kinase inhibitor. Gastrointestinal complications (i.e. diarrhea, vomiting and nausea) are the most common adverse events. In this study, we aimed to investigate (1) the overall incidence and relative risk (RR) of diarrhea, vomiting and nausea and (2) whether combination neratinib therapy increased the incidence of gastrointestinal complications versus neratinib alone. Methods: Relevant studies were identified from the PubMed database, from abstracts presented at the American Society of Clinical Oncology annual conference and from the Web of Science database. Incidences, RRs, and 95% confidence intervals (CIs) were calculated. Results: The incidences of all-grade diarrhea, vomiting and nausea in the neratinib groups were 89% (95% CI = 77–95%), 31% (95% CI = 25–37%) and 44% (95% CI = 33–55%), respectively. The neratinib arms significantly increased the risk of diarrhea and vomiting in comparison with the control groups (diarrhea: all-grade, RR = 2.06, 95% CI = 1.38–3.08, P = 0.0004; grade 3/4, RR = 8.77, 95% CI = 2.91–26.40, P = 0.0001; vomiting: all-grade, RR = 2.02, 95% CI = 1.10–3.71, P = 0.02; grade 3/4, RR = 7.10, 95% CI = 3.33–15.15, P Conclusions: Our meta-analysis demonstrates that the neratinib arms are associated with a significantly increased risk of diarrhea and vomiting. |
| Databáze: | OpenAIRE |
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