The role of intraarterial vasodilators in the treatment of inadvertent intraarterial injection injuries
Autor: | Christopher R. Crawford, William Terranova |
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Rok vydání: | 1990 |
Předmět: |
medicine.medical_specialty
Necrosis Reserpine medicine.medical_treatment Vasodilation medicine Animals Ear External Thiopental Tolazoline Saline Chemotherapy business.industry Vasospasm Arteries medicine.disease Surgery Disease Models Animal medicine.anatomical_structure Injections Intra-Arterial Anesthesia Rabbits medicine.symptom business medicine.drug Artery |
Zdroj: | Annals of plastic surgery. 25(4) |
ISSN: | 0148-7043 |
Popis: | Inadvertent arterial injections, both in cases of drug addiction and in iatrogenic situations, often result in significant loss of tissue and, eventually, loss of function distal to the injection site. Previous experimental studies regarding the effectiveness of agents to reverse vasospasm have been inconclusive. A recent clinical report, however, suggested that intraarterial injection of reserpine was affective in limiting tissue necrosis. This experiment was designed to study the affect of intraarterially injected reserpine and tolazoline hydrochloride in a rabbit ear model of necrosis following intraarterial injection of pentothal. Six groups of 5 rabbits each were studied. Animals in Group 1 received intraarterial saline injections. Animals in Group 2 received intraarterial pentothal. Animals in Group 3 received intraarterially injected pentothal plus intraarterial reserpine 30 minutes later. Animals in Group 4 received intraarterially injected pentothal plus intraarterial tolazoline 30 minutes later. Animals in Group 5 received intraarterially injected pentothal plus intraarterially injected reserpine and intraarterially injected tolazoline both administered immediately. Animals in Group 6 received intraarterially injected pentothal plus intraarterially injected reserpine and intraarterially injected tolazoline, both administered 30 minutes later. Results showed no significant difference in the amount of tissue necrosis between treated and untreated animals. We conclude that the use of intraarterial spasmolytic agents has no effect on the course of tissue necrosis after inadvertent intraarterial injections. |
Databáze: | OpenAIRE |
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