Comparison of microdose flare-up and antagonist multiple-dose protocols for poor-responder patients: a randomized study
| Autor: | Aygul Demirol, Timur Gurgan |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Infertility medicine.medical_specialty Randomization medicine.medical_treatment Fertilization in Vitro Contraceptives Oral Hormonal law.invention Gonadotropin-Releasing Hormone Hormone Antagonists Ovulation Induction MicroDose Randomized controlled trial Pregnancy law Internal medicine Humans Medicine Prospective cohort study Gynecology Assisted reproductive technology business.industry Pregnancy Outcome Antagonist Obstetrics and Gynecology Embryo Transfer medicine.disease Combined Modality Therapy Treatment Outcome Reproductive Medicine Female business Infertility Female |
| Zdroj: | Fertility and Sterility. 92:481-485 |
| ISSN: | 0015-0282 |
| Popis: | Objective To compare the efficacy of the microdose flare-up and multiple-dose antagonist protocols for poor-responder patients in intracytoplasmic sperm injection–ET cycles. Design A randomized, prospective study. Setting Center for assisted reproductive technology in Turkey. Patient(s) Ninety patients with poor ovarian response in a minimum of two previous IVF cycles. Intervention(s) All women were prospectively randomized into two groups by computer-assisted randomization. The patients in group 1 were stimulated according to the microdose flare-up protocol (n = 45), while the patients in group 2 were stimulated according to antagonist multiple-dose protocol (n = 45). Main Outcome Measure(s) The mean number of mature oocytes retrieved was the primary outcome measure, and fertilization rate, implantation rate per embryo, and clinical pregnancy rates were secondary outcome measures. Result(s) The mean age of the women, the mean duration of infertility, basal FSH level, and the number of previous IVF cycles were similar in both groups. The total gonadotropin dose used was significantly higher in group 2, while the number of oocytes retrieved was significantly greater in group 1. Although the fertilization and clinical pregnancy rates were nonsignificantly higher in group 1 compared with group 2, the implantation rate was significantly higher in the microdose flare-up group than in the multiple-dose antagonist group (22% vs. 11%). Conclusion(s) The microdose flare-up protocol seems to have a better outcome in poor-responder patients, with a significantly higher mean number of mature oocytes retrieved and higher implantation rate. |
| Databáze: | OpenAIRE |
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