Failed cooperative, but not competitive, interaction between large-scale brain networks impairs working memory in schizophrenia
| Autor: | Qiang Luo, Jianfeng Feng, Zhening Liu, Lena Palaniyappan, Z. Xue, Shuqiao Yao, William T. Pu |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Adolescent Models Neurological Context (language use) Neuropsychological Tests Brain mapping Young Adult 03 medical and health sciences Cognition 0302 clinical medicine Image Processing Computer-Assisted medicine Humans Attention Social Behavior Applied Psychology Default mode network Cognitive deficit Psychiatric Status Rating Scales Brain Mapping medicine.diagnostic_test Echo-Planar Imaging Working memory Brain medicine.disease Psychiatry and Mental health Memory Short-Term 030104 developmental biology Schizophrenia Case-Control Studies Female Nerve Net medicine.symptom Functional magnetic resonance imaging Psychology Neuroscience 030217 neurology & neurosurgery Cognitive psychology |
| Zdroj: | Psychological Medicine. 46:1211-1224 |
| ISSN: | 1469-8978 0033-2917 |
| Popis: | BackgroundA large-scale network named the default mode network (DMN) dynamically cooperates and competes with an external attention system (EAS) to facilitate various cognitive functioning that is prominently impaired in schizophrenia. However, it is unclear whether the cognitive deficit in schizophrenia is related to the disrupted competition and/or cooperation between these two networks.MethodA total of 35 schizophrenia patients and 30 healthy controls were scanned using gradient-echo echo-planar imaging during n-back working memory (WM) processing. Brain activities of the DMN and EAS were measured using general linear modelling of the functional magnetic resonance imaging data. Dynamic interaction between the DMN and EAS was decomposed into two directions using Granger causality analysis.ResultsWe observed a significant failure of DMN suppression in patients with schizophrenia, which was significantly related to WM/attentional deficit. Granger causality modelling showed that in healthy controls, while the EAS inhibitorily influenced the DMN, the DMN exerted an ‘excitatory’ or cooperative influence back on the EAS, especially in those with lower WM accuracy. In schizophrenia, this ‘excitatory’ DMN→EAS influence within the reciprocal EAS–DMN loop was significantly reduced, especially in patients with WM/attentional deficit.ConclusionsThe dynamic interaction between the DMN and EAS is likely to be comprised of both competitive and cooperative influences. In healthy controls, both the ‘inhibitory’ EAS→DMN interaction and ‘excitatory’ DMN→EAS interaction are correlated with WM performance. In schizophrenia, reduced ‘cooperative’ influence from the DMN to dorsal nodes of the EAS occurs in the context of non-suppression of the DMN and may form a possible pathophysiological substrate of WM deficit and attention disorder. |
| Databáze: | OpenAIRE |
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