Androgen receptor gene CAG and GGN repeat lengths as predictors of recovery of spermatogenesis following testicular germ cell cancer treatment
| Autor: | Olof Ståhl, Stefan Arver, Eva Cavallin-Ståhl, Gabriella Cohn-Cedermark, Aleksander Giwercman, Karolina Bogefors, Jakob Eberhard, Yvonne Lundberg Giwercman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Adolescent Urology media_common.quotation_subject Antineoplastic Agents Fertility Biology lcsh:RC870-923 sperm number Andrology Young Adult 03 medical and health sciences 0302 clinical medicine CAG and GGN repeat Testicular Neoplasms Trinucleotide Repeats Predictive Value of Tests Semen androgen receptor medicine Humans Young adult Spermatogenesis Receptor Testicular cancer media_common 030219 obstetrics & reproductive medicine Radiotherapy Recovery of Function General Medicine Middle Aged Neoplasms Germ Cell and Embryonal medicine.disease lcsh:Diseases of the genitourinary system. Urology Sperm testicular cancer Androgen receptor Receptors Androgen 030220 oncology & carcinogenesis Predictive value of tests Original Article |
| Zdroj: | Asian Journal of Andrology, Vol 19, Iss 5, Pp 538-542 (2017) Asian Journal of Andrology |
| ISSN: | 1745-7262 |
| Popis: | Spermatogenesis is an androgen-regulated process that depends on the action of androgen receptor (AR). Sperm production may be affected in men treated for testicular cancer (TC), and it is important to identify the factors influencing the timing of spermatogenesis recovery following cancer treatment. It is known that the CAG and GGN repeat numbers affect the activity of the AR; therefore, the aim of this study is to investigate if the CAG and GGN polymorphisms in the AR gene predict recovery of sperm production after TC treatment. TC patients (n = 130) delivered ejaculates at the following time points: postorchiectomy and at 6, 12, 24, 36, and 60 months posttherapy (T0, T6, T12, T24, T36, and T60). The CAG lengths were categorized into three groups, 23 CAG, and the GGN tracts were also categorized into three groups, 23 GGN. At T12, men with 22-23 CAG presented with a statistically significantly (P = 0.045) lower sperm concentration than those with other CAG numbers (8.4 × 106 ml−1 vs 16 × 106 ml−1 ; 95% CI: 1.01-2.65). This association was robust to omitting adjustment for treatment type and sperm concentration at T0 (P = 0.021; 3.7 × 106 ml−1 vs 10 × 106 ml−1 ; 95% CI: 1.13-4.90). The same trends were observed for total sperm number. The least active AR variant seems to be associated with a more rapid recovery of spermatogenesis. This finding adds to our understanding of the biology of postcancer therapy recovery of fertility in males and has clinical implications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|