Asymmetric and Asynchronous Infantile Spasms
| Autor: | Gaily Ek, Shewmon Da, Curran Jg, Chugani Ht |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Video Recording Neurological examination Partial Motor Seizure Audiology Electroencephalography Central nervous system disease 03 medical and health sciences Epilepsy 0302 clinical medicine Seizures otorhinolaryngologic diseases medicine Humans 030304 developmental biology Cerebral Cortex Neurologic Examination 0303 health sciences medicine.diagnostic_test Infant Magnetic resonance imaging West Syndrome Syndrome medicine.disease nervous system diseases body regions stomatognathic diseases medicine.anatomical_structure Neurology Cerebral cortex Child Preschool Anesthesia Neurology (clinical) Psychology Spasms Infantile Psychomotor Performance 030217 neurology & neurosurgery |
| Zdroj: | Epilepsia. 36:873-882 |
| ISSN: | 1528-1167 0013-9580 |
| DOI: | 10.1111/j.1528-1157.1995.tb01630.x |
| Popis: | Infantile spasms most commonly show symmetric behavioral and electroencephalogram (EEG) manifestations. Asymmetric and asynchronous behavioral spasms occur occasionally, but their relationship to ictal EEG and to other localizing studies has not received much attention. We reviewed 75 consecutive video-EEG recordings, done at UCLA from 1982 to 1992, that contained infantile spasms; 8,680 spasms were scored for behavioral and EEG asymmetry and asynchrony. Of the recorded spasms, 25% were asymmetric and 7% were asynchronous. Most asymmetric of asynchronous spasms were associated with an ictal EEG discharge that was contralateral to the behaviorally more involved side. In 12 of the 60 patients (20%), more than half of the recorded spasms were asymmetric of asynchronous. Baseline EEG, magnetic resonance imaging, positron emission tomography, and neurological examination revealed structural and functional brain abnormalities that involved the contralateral central region significantly more often in the children with > 50% spasm asymmetry or asynchrony than in the other children. Partial seizures with lateralized motor behavior also occurred frequently in these children. The findings suggest that asymmetric and asynchronous spasms are generated by a cortical epileptogenic region that involves the primary sensorimotor area. The combination of asymmetric and asynchronous infantile spasms, partial motor seizures involving the same side of the body, and pathology in the contralateral central region may represent a unique subset of symptomatic localization-related infantile epilepsy. |
| Databáze: | OpenAIRE |
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