Coronary arterioles in type 2 diabetic (db/db) mice undergo a distinct pattern of remodeling associated with decreased vessel stiffness
| Autor: | James A. Stewart, Maarten L. Galantowicz, Kurt J. Varner, Flavia M. Souza-Smith, Aaron J. Trask, Mary J. Cismowski, Kirk R. Hutchinson, Paige S. Katz, Pamela A. Lucchesi, Kevin C Lord |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Physiology Femoral artery Type 2 diabetes Article Collagen Type I Mice Arteriole Physiology (medical) medicine.artery Internal medicine medicine Animals Pulse wave velocity Electrical impedance myography Reverse Transcriptase Polymerase Chain Reaction business.industry Coronary flow reserve Type 2 Diabetes Mellitus Diabetic mouse medicine.disease Coronary Vessels Elasticity Mice Mutant Strains Elastin Arterioles Endocrinology Diabetes Mellitus Type 2 Cardiology and Cardiovascular Medicine business |
| Zdroj: | Basic Research in Cardiology. 106:1123-1134 |
| ISSN: | 1435-1803 0300-8428 |
| DOI: | 10.1007/s00395-011-0201-0 |
| Popis: | Little is known about the impact of type 2 diabetes mellitus (DM) on coronary arteriole remodeling. The aim of this study was to determine the mechanisms that underlie coronary arteriole structural remodeling in type 2 diabetic (db/db) mice. Passive structural properties of septal coronary arterioles isolated from 12- to 16-week-old diabetic db/db and control mice were assessed by pressure myography. Coronary arterioles from 12-week-old db/db mice were structurally similar to age-matched controls. By 16 weeks of age, coronary wall thickness was increased in db/db arterioles (p |
| Databáze: | OpenAIRE |
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