Elevated circulating heat shock protein 70 and its antibody concentrations in chronic spontaneous urticaria
| Autor: | Alicja Kasperska-Zając, Aleksandra Damasiewicz-Bodzek, Alicja Grzanka, Agnieszka Skrzypulec-Frankel, Katarzyna Bieniek, Krystyna Tyrpień-Golder |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Urticaria anti-Hsp70 antibody Immunology heat shock protein Inflammation Severity of Illness Index Antibodies Hsp70 Pathogenesis Young Adult 03 medical and health sciences Immune system acute phase response Heat shock protein medicine Humans Immunology and Allergy HSP70 Heat-Shock Proteins Letter to the Editor Pharmacology biology Chemistry Acute-phase protein Middle Aged Cytoprotection Cell biology C-Reactive Protein chronic spontaneous urticarial 030104 developmental biology Chronic Disease biology.protein Female Antibody medicine.symptom Biomarkers |
| Zdroj: | International Journal of Immunopathology and Pharmacology |
| ISSN: | 2058-7384 |
| DOI: | 10.1177/0394632017750440 |
| Popis: | Heat shock proteins (Hsp) play a complex role in cytoprotection, inflammation, and function of the immune system. They may be involved in pathogenesis of various diseases. Our aim was to determine circulating Hsp70 and anti-Hsp70 antibodies concentrations in patients with chronic spontaneous urticaria (CSU). Concentrations of Hsp70 in plasma and anti-Hsp70 antibodies in serum as well as serum C-reactive protein (CRP) were measured in CSU patients and in the controls. Plasma Hsp70 concentrations were significantly higher in CSU (all) and mild CSU patients as compared with the controls. Moderate–severe CSU patients tended to show higher Hsp70 concentration as compared with the controls, but not with mild activity of the disease. There were no significant differences in Hsp70 concentration between moderate–severe and mild CSU patients. Serum anti-Hsp70 antibodies concentrations were significantly higher in CSU (all) and mild CSU in comparison to the controls. Association was observed between anti-Hsp70 antibodies and increased CRP concentration; however, no correlation between anti-Hsp70 and Hsp70 concentrations was seen in the patients. It seems that up-regulation of Hsp70 in CSU may induce marked increase in anti-Hsp70 antibodies production, which are accompanied by parallel changes in CRP concentration. We suggest that Hsp may be released in CSU in response to stressful stimuli, such as inflammation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|