Distribution and predictive value of initial presenting symptoms in spinal metastases from primary cancer patients

Autor: Ye Chen, Haifeng Wei, Xin Gao, Jianru Xiao, Wei Xu, Dongyu Peng, Shaohui He
Rok vydání: 2020
Předmět:
Zdroj: European Spine Journal. 29:3148-3156
ISSN: 1432-0932
0940-6719
Popis: Primary cancer patients may have some symptoms and develop spinal metastases in their disease progression. This study was to report the distribution and predictive value of specific initial presenting symptoms in patients with spine metastatic disease. The clinical information about patients with primary cancers was retrospectively collected and analyzed at their initial diagnosis from January 2008 to December 2017. The distribution and specific value of initial presenting symptoms were analyzed in predicting spinal metastases. A total of 14,603 cancer patients were finally included, of whom 1665 (11.4%) cases were confirmed with spinal metastases. 41.55% (6067/14,603) patients had initial presenting symptoms, while 92.19% (1535/1665) patients with spinal metastases presented at least one initial presenting symptoms. Among 6269 patients with symptoms, 1535 (24.49%) were diagnosed with spinal metastases. Factors including primary tumor type, local pain, night-aggravating pain, limb numbness, limb weakness, unstable gait, claudication, loss of sphincter control, and weight loss are associated with the distribution of spinal metastases. The pooled sensitivity, specificity, positive predictive value, and negative predictive value were 90.9% (89.4–92.2%), 64.9% (64.0–65.7%), 24.99% (23.91–26.11%), and 98.23% (97.92–98.50%), respectively. Positive likelihood ratio of “night-aggravating pain” was 33.25 (12.65–87.36) and 17.26 (12.25–24.32) in patients
Databáze: OpenAIRE
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