The effects of disodium cromoglycate on enhanced adherence of Haemophilus influenzae to A549 cells infected with respiratory syncytial virus
| Autor: | Chie Fukasawa, Naruhiko Ishiwada, Junko Ogita, Yoichi Kohno, Haruka Hishiki |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Haemophilus Infections
Paramyxoviridae viruses Secondary infection Respiratory Mucosa Respiratory Syncytial Virus Infections medicine.disease_cause Bacterial Adhesion Dexamethasone Microbiology Haemophilus influenzae Pneumovirinae Cell Line Tumor Haemophilus Cromolyn Sodium otorhinolaryngologic diseases medicine Humans Anti-Asthmatic Agents Mononegavirales Glucocorticoids biology Pasteurellaceae virus diseases Epithelial Cells respiratory system biology.organism_classification Intercellular Adhesion Molecule-1 Bronchodilator Agents Respiratory Syncytial Viruses Androstadienes medicine.anatomical_structure Pediatrics Perinatology and Child Health Immunology Fluticasone Respiratory tract |
| Zdroj: | Pediatric research. 66(2) |
| ISSN: | 1530-0447 |
| Popis: | Nontypeable Haemophilus influenzae (NTHi) secondary infection often complicates respiratory syncytial virus (RSV) infections. Previous studies have revealed that RSV infections enhance NTHi adherence to airway epithelial cells. In this study, we investigated the effects of disodium cromoglycate (DSCG) and corticosteroids, which are frequently used for the treatment of wheezing often related to RSV infections, on the adherence of NTHi to RSV-infected A549 cells. DSCG inhibited enhanced adherence of NTHi to RSV-infected A549 cells, whereas dexamethasone (Dex) and fluticasone propionate (Fp) did not. DSCG suppressed the expression of ICAM-1, which is one of the NTHi receptors. Furthermore, DSCG exhibited an inhibitory effect on RSV infections. It is suggested that DSCG exerts an anti-RSV effect, and consequently attenuates the expression of NTHi receptors. |
| Databáze: | OpenAIRE |
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