Neurogenesis in the rat neonate's hippocampus with maternal short‐term REM sleep deprivation restores by royal jelly treatment
| Autor: | Melikasadat Jameie, Seyed Behnamedin Jameie, Vahid Pirhajati, Atena Khodaverdiloo, Mona Farhadi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
hippocampus Rapid eye movement sleep Neurosciences. Biological psychiatry. Neuropsychiatry Neuroprotection royal jelly Behavioral Neuroscience symbols.namesake Neurotrophic factors Pregnancy Internal medicine Medicine Hippocampus (mythology) Animals Rats Wistar Brain-derived neurotrophic factor brain‐derived neurotrophic factor business.industry musculoskeletal neural and ocular physiology Neurogenesis Fatty Acids Original Articles medicine.disease Rats neurogenesis Endocrinology Nissl body symbols Sleep Deprivation Original Article Female business psychological phenomena and processes rapid eye movement sleep deprivation RC321-571 |
| Zdroj: | Brain and Behavior, Vol 11, Iss 12, Pp n/a-n/a (2021) Brain and Behavior |
| ISSN: | 2162-3279 |
| Popis: | Background Numerous studies have shown the effects of rapid eye movement sleep deprivation (REM‐SD) on behavior and brain structures. The impact of REM‐SD on learning and memory, thus neurogenesis, has been reported in previous studies. Royal jelly (RJ) is known as the wealthiest biological nutrient with various physiological properties. This study aimed to study the possible effect of RJ on neurogenesis of the rat hippocampus neonates following exposure of mother to REM‐SD during pregnancy. Methods Thirty neonate rats from 15 pregnant Wistar rats were used. To induce REM‐SD, the flowerpot method was used. The pregnant rats were divided into five groups (n = 3): group 1, no treatment; group 2, REM‐SD; groups 3, 4, and 5, REM‐SD +RJ. The former group received 72 h REM‐SD during pregnancy (days 7, 14, 21), and the latter group received REM‐SD + RJ (three trial groups). At week 4, the rat neonates of all groups were sacrificed (n = 6 each group). Their brains were fixed, removed, and prepared for Nissl and Hoechst 33342 staining. By using real time polymerase chain reaction methode the brain‐derived neurotrophic factor BDNF gene expression was studied (RT‐PCR), brain‐derived neurotrophic factor (BDNF) gene expression was studied. The results were analyzed statistically, and the Pv In order to study the effect of royal jelly (RJ) on neurogenesis following early exposure to rapid eye movement sleep deprivation (REM‐SD) in rat neonates, the present study designed to study the effect of Royal Jelly. We believe that RJ has a dual role via brain‐derived neurotrophic factor (BDNF) following REM‐SD; increasing the expression of BDNF in the hippocampus stimulates cell proliferation and differentiation and inhibits apoptosis. |
| Databáze: | OpenAIRE |
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