Enhanced thermal effect using magnetic nano-particles during high-intensity focused ultrasound

Autor: Dushyanth Giridhar, Surendra B. Devarakonda, Matthew R. Myers, Rupak K. Banerjee, Seyed Ahmad Reza Dibaji
Jazyk: angličtina
Rok vydání: 2017
Předmět:
medicine.medical_treatment
Cancer Treatment
Extrapolation
Nanoparticle
lcsh:Medicine
Lesion volume
02 engineering and technology
Pathology and Laboratory Medicine
Mechanical Treatment of Specimens
Diagnostic Radiology
0302 clinical medicine
Medicine and Health Sciences
Nanotechnology
lcsh:Science
Tomography
Numerical Analysis
Multidisciplinary
Phantoms
Imaging
Physics
Radiology and Imaging
Temperature
021001 nanoscience & nanotechnology
Ablation
Condensed Matter Physics
Oncology
030220 oncology & carcinogenesis
Physical Sciences
Engineering and Technology
Phonons
medicine.symptom
0210 nano-technology
Research Article
Materials science
Imaging Techniques
Sonication
Thermal effect
Neuroimaging
Research and Analysis Methods
Focused ultrasound
Lesion
03 medical and health sciences
Magnetics
Signs and Symptoms
Diagnostic Medicine
medicine
Humans
Particle Physics
lcsh:R
Collective Excitations
Biology and Life Sciences
Acoustics
X-Ray Microtomography
High-intensity focused ultrasound
Computed Axial Tomography
Specimen Preparation and Treatment
Lesions
Nanoparticles
High-Intensity Focused Ultrasound Ablation
lcsh:Q
Mathematics
Biomedical engineering
Neuroscience
Zdroj: PLoS ONE, Vol 12, Iss 4, p e0175093 (2017)
PLoS ONE
ISSN: 1932-6203
Popis: Collateral damage and long sonication times occurring during high-intensity focused ultrasound (HIFU) ablation procedures limit clinical advancement. In this reserarch, we investigated whether the use of magnetic nano-particles (mNPs) can reduce the power required to ablate tissue or, for the same power, reduce the duration of the procedure. Tissue-mimicking phantoms containing embedded thermocouples and physiologically acceptable concentrations (0%, 0.0047%, and 0.047%) of mNPs were sonicated at acoustic powers of 5.2 W, 9.2 W, and 14.5 W, for 30 seconds. Lesion volumes were determined for the phantoms with and without mNPs. It was found that with the 0.047% mNP concentration, the power required to obtain a lesion volume of 13 mm3 can be halved, and the time required to achieve a 21 mm3 lesion decreased by a factor of 5. We conclude that mNPs have the potential to reduce damage to healthy tissue, and reduce the procedure time, during tumor ablation using HIFU.
Databáze: OpenAIRE
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