Correction: Alexandre-Gouabau et al. 'Comprehensive Preterm Breast Milk Metabotype Associated with Optimal Infant Early Growth Pattern', Nutrients, 2019, 11, 528
| Autor: | Anne-Lise Royer, Agnès David-Sochard, Dominique Darmaun, Yann Guitton, Jean-Christophe Rozé, Thomas Moyon, Sophie Cholet, Hélène Billard, François Fenaille, Clair-Yves Boquien, Marie-Cécile Alexandre-Gouabau |
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| Přispěvatelé: | Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Service de Pharmacologie et Immunoanalyse (SPI), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire d'Etude du Métabolisme des Médicaments (LEMM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Médicaments et Technologies pour la Santé (MTS), Laboratoire d'étude des Résidus et Contaminants dans les Aliments (LABERCA), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Alexandre-Gouabau, Marie Cécile |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 030309 nutrition & dietetics Physiology 030209 endocrinology & metabolism lcsh:TX341-641 Breast milk Biology Article preterm infant Cohort Studies 03 medical and health sciences lipidome 0302 clinical medicine Nutrient Child Development growth trajectory breast milk metabolome Humans Metabolomics glycome Food and Nutrition Infant Nutritional Physiological Phenomena ComputingMilieux_MISCELLANEOUS 0303 health sciences Nutrition and Dietetics Milk Human Correction Infant Lipid Metabolism n/a free amino acid Alimentation et Nutrition Carbohydrate Metabolism Female lcsh:Nutrition. Foods and food supply [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Infant Premature Food Science |
| Zdroj: | Nutrients Nutrients, MDPI, 2020, 12 (1), pp.162. ⟨10.3390/nu12010162⟩ Nutrients 1 (12), 162. (2020) Nutrients, Vol 12, Iss 1, p 162 (2020) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu12010162⟩ |
| Popis: | Early nutrition impacts preterm infant early growth rate and brain development but can have long lasting effects as well. Although human milk is the gold standard for feeding new born full-term and preterm infants, little is known about the effects of its bioactive compounds on breastfed preterm infants’ growth outcomes. This study aims to determine whether breast milk metabolome, glycome, lipidome, and free-amino acids profiles analyzed by liquid chromatography-mass spectrometry had any impact on the early growth pattern of preterm infants. The study population consisted of the top tercile-Z score change in their weight between birth and hospital discharge (“faster grow”, n = 11) and lowest tercile (“slower grow”, n = 15) from a cohort of 138 premature infants (27–34 weeks gestation). This holistic approach combined with stringent clustering or classification statistical methods aims to discriminate groups of milks phenotype and identify specific metabolites associated with early growth of preterm infants. Their predictive reliability as biomarkers of infant growth was assessed using multiple linear regression and taking into account confounding clinical factors. Breast-milk associated with fast growth contained more branched-chain and insulino-trophic amino acid, lacto-N-fucopentaose, choline, and hydroxybutyrate, pointing to the critical role of energy utilization, protein synthesis, oxidative status, and gut epithelial cell maturity in prematurity. |
| Databáze: | OpenAIRE |
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