Association of Borderline Oxacillin-Susceptible Strains of Staphylococcus aureus with Surgical Wound Infections
| Autor: | Charles W. Stratton, David C. Classen, Allen B. Kaiser, Douglas S. Kernodle |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Microbiology (medical)
Staphylococcus aureus Micrococcaceae medicine.drug_class medicine.medical_treatment Antibiotics Cefazolin Microbial Sensitivity Tests Penicillins medicine.disease_cause Microbiology medicine Surgical Wound Infection Oxacillin Antibacterial agent Chemotherapy biology business.industry Bacteriology Drug Resistance Microbial Surgical wound biology.organism_classification Regimen business medicine.drug |
| Zdroj: | Journal of Clinical Microbiology. 36:219-222 |
| ISSN: | 1098-660X 0095-1137 |
| DOI: | 10.1128/jcm.36.1.219-222.1998 |
| Popis: | Staphylococcus aureus isolates which produce type A staphylococcal β-lactamase have been associated with wound infections complicating the use of cefazolin prophylaxis in surgery. To further evaluate this finding, 215 wound isolates from 14 cities in the United States were characterized by antimicrobial susceptibility and β-lactamase type and correlated with the preoperative prophylactic regimen. Borderline-susceptible S. aureus isolates of phage group 5 (BSSA-5), which produce large amounts of type A β-lactamase and exhibit borderline susceptibility to oxacillin, comprised a greater percentage of the 120 wound isolates associated with cefazolin prophylaxis than they did of the 95 isolates associated with other prophylactic regimens (25% versus 12.6%, respectively; P < 0.05). In contrast, methicillin-resistant S. aureus isolates were distributed evenly between the two groups (8.3% versus 11.6%, respectively). In vitro assays demonstrated that cefazolin was hydrolyzed faster by BSSA-5 strains than by other β-lactamase-producing, methicillin-susceptible strains (1.54 versus 0.50 μg/min/10 8 CFU, respectively; P < 0.0001). These data demonstrate that BSSA-5 strains are a distinct subpopulation of methicillin-susceptible S. aureus which frequently cause deep surgical wound infections. Cefazolin use in prophylaxis is a risk factor for BSSA-5 infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|