Effects of occupational exposure to respirable quartz dust on acute myocardial infarction
| Autor: | Johannes Gellissen, Dagmar Pattloch, Matthias Möhner |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Silicosis Myocardial Infarction acute myocardial infarction Cumulative Exposure Miners Cohort Studies 03 medical and health sciences 0302 clinical medicine Respirable Quartz Germany Occupational Exposure Internal medicine Epidemiology medicine respirable quartz Humans Myocardial infarction Workplace Inhalation Exposure business.industry Public Health Environmental and Occupational Health Dust Quartz nested case–control study Middle Aged medicine.disease Logistic Models 030228 respiratory system Case-Control Studies 030220 oncology & carcinogenesis Cohort Nested case-control study epidemiology Female Occupational exposure business dusts |
| Zdroj: | Occupational and Environmental Medicine |
| ISSN: | 1470-7926 1351-0711 |
| DOI: | 10.1136/oemed-2018-105540 |
| Popis: | ObjectivesThe aim of this study is to investigate the effects of occupational exposure to respirable quartz (RQ) on first acute myocardial infarction (AMI). RQ causes pulmonary diseases like silicosis and has also been linked to cardiovascular diseases. Inflammation is hypothesised as the underlying pathway.MethodsWe performed a 1:3 matched case–control study nested in a cohort of male uranium miners. We included cases (identified from hospital records and validated according to WHO criteria) who had suffered their first AMI while still employed and ResultsThe study base comprised 292 matched sets. The cumulative exposure ranged from 0 to 38.9 mg/m3-years RQ. The adjusted OR of the highest RQ tertile (>14.62 mg/m3-years) was 1.27 (95% CI 0.82 to 1.98). However, for miners born after 1928 and hired in the earliest recruitment era (1946–1954), a significantly elevated risk was seen in the highest RQ tertile (OR=6.47 [95% CI 1.33 to 31.5]; 50 matched sets).ConclusionsAn impact of quartz dust on first AMI was observed only in a small subgroup that had virtually no pre-exposure to RQ. Further studies on the basis of complete occupational history are required to substantiate this finding. |
| Databáze: | OpenAIRE |
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