Serum phospholipid omega-3 polyunsaturated fatty acids and insulin resistance in type 2 diabetes mellitus and non-alcoholic fatty liver disease
| Autor: | Da-jun Lou, Qiao-ying You, Xu-wei Si, Duo Li, Li-li Guan, Qi-qian Zhu, Zhong-ming Yu, Ai-zhen Zhang |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Disease digestive system Endocrinology Insulin resistance Non-alcoholic Fatty Liver Disease Diabetes mellitus Internal medicine Fatty Acids Omega-3 Internal Medicine Humans Medicine Phospholipids Aged chemistry.chemical_classification business.industry Fatty liver nutritional and metabolic diseases Type 2 Diabetes Mellitus Serum phospholipid Middle Aged medicine.disease digestive system diseases Diabetes Mellitus Type 2 chemistry Case-Control Studies Female Insulin Resistance business Homeostasis Polyunsaturated fatty acid |
| Zdroj: | Journal of Diabetes and its Complications. 28:711-714 |
| ISSN: | 1056-8727 |
| DOI: | 10.1016/j.jdiacomp.2014.04.008 |
| Popis: | To investigate the relationship between serum phospholipid omega-3 polyunsaturated fatty acids (ω-3 PUFAs) and insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD).51 patients with T2DM and NAFLD (T2DM+NAFLD group), 50 with T2DM alone (T2DM group), 45 with NAFLD alone (NAFLD group), and 42 healthy control subjects (NC group) were studied. Serum ω-3 PUFA profiles were analyzed by gas chromatography, and alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltransferase (GGT), and serum lipid concentrations were measured. Insulin resistance was assessed by the homeostasis model assessment method (HOMA-IR).HOMA-IR levels were higher in the T2DM+NAFLD group than in the T2DM, NAFLD and NC groups (p0.05), as were ALT, AST, GGT, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) concentrations (p0.05). Conversely, serum ω-3 PUFA levels were significantly lower in the T2DM+NAFLD group than in the other groups (p0.05). The ω-3 PUFA level was negatively correlated with HOMA-IR, TC, LDL-C and TG.Serum phospholipid ω-3 PUFA levels were significantly decreased in patients with T2DM and NAFLD, and were negatively related with insulin resistance. Thus, reduced ω-3 PUFAs may play an important role in the development of T2DM and NAFLD. |
| Databáze: | OpenAIRE |
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