Solvent‐Free Williamson Synthesis: An Efficient, Simple, and Convenient Method for Chemoselective Etherification of Phenols and Bisphenols

Autor:	Masumeh Mosharafian, H. Javaherian Naghash, Ahmad Reza Massah, Mohamad Adibnejad, Ahamad R. Momeni, Hamid Aliyan
Rok vydání:	2007
Předmět:	Williamson ether synthesis chemistry.chemical_compound Solvent free Benzyl chloride Chemistry Yield (chemistry) Organic Chemistry Organic chemistry Solid base General Medicine Phenols Environmentally friendly
Zdroj:	Synthetic Communications. 37:1807-1815
ISSN:	1532-2432 0039-7911
DOI:	10.1080/00397910701316268
Popis:	Etherification of phenols with dimethyl‐ and diethylsulfates and benzyl chloride was performed efficiently in the presence of a suitable solid base, NaHCO3 or K2CO3, under solvent‐free conditions. The reaction proceeded rapidly at low temperature, and the corresponding ethers were obtained with high purity and excellent yield. Selective etherification of electron‐poor phenols in the presence of electron‐rich ones and also selective mono‐etherification of bisphenols are the noteworthy advantages of this method. This method is environmentally friendly.
Databáze:	OpenAIRE
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