Emergence of a novel subpopulation of CC398 Staphylococcus aureus infecting animals is a serious hazard for humans
| Autor: | Patrice Francois, Jean-Baptiste Franck, Roland Quentin, Xavier Bertrand, Nathalie van der Mee-Marquet, Jan Kluytmans, Anna Rita Corvaglia, Marisa Haenni, Myriam Girard |
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| Přispěvatelé: | Service de bactériologie et d'hygiène hospitalière [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours, Genomic Research Laboratory, Geneva University Hospital (HUG), Laboratoire d'études et de recherches en pathologie bovine et hygiène des viandes, Agence Française de Sécurité Sanitaire des Aliments (AFSSA), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Laboratory for Microbiology and Infection Control, Amphia Hospital, CHRU Tours-CHU Trousseau [APHP], Geneva University Hospital ( HUG ), AFSSA, Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ), Infectiologie et Santé Publique ( ISP ), Université de Tours-IFR136, Medical Microbiology and Infection Prevention, CCA - Immuno-pathogenesis, Van Der Mee-Marquet, Nathalie, Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT) |
| Rok vydání: | 2014 |
| Předmět: |
staphylococcus aureus
Microbiology (medical) Lineage (genetic) infection humaine lcsh:QR1-502 Virulence Biology medicine.disease_cause infection animale virulence factor genome plasticity Microbiology lcsh:Microbiology Virulence factor lysogeny Bacteriophage Antibiotic resistance bacteriophage [ SDV.MP ] Life Sciences [q-bio]/Microbiology and Parasitology Lysogenic cycle medicine Original Research Article Prophage Microbiology and Parasitology biology.organism_classification Microbiologie et Parasitologie 3. Good health facteur de virulence [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology Staphylococcus aureus genome content Public Health |
| Zdroj: | Frontiers in Microbiology Frontiers in Microbiology, Frontiers Media, 2015, 5, ⟨10.3389/fmicb.2014.00652⟩ Frontiers in microbiology Frontiers in microbiology, Frontiers Research Foundation, 2013, 5, pp.652 Frontiers in Microbiology, Vol 5 (2014) Frontiers in Microbiology, 5:652. Frontiers Media S.A. Frontiers in microbiology (5), 1-9. (2014) Mee-Marquet, N, Corvaglia, A, Haenni, M, Bertrand, X, Franck, J B, Kluijtmans, J A J W, Girard, M, Quentin, R & Francois, P 2014, ' Emergence of a novel subpopulation of CC398 Staphylococcus aureus infecting animals is a serious hazard for humans ', Frontiers in Microbiology, vol. 5, 652 . https://doi.org/10.3389/fmicb.2014.00652 |
| ISSN: | 1664-302X |
| Popis: | International audience; Until recently, Staphylococcus aureus from clonal complex (CC)398 were mostly described as colonizing asymptomatic raised pigs and pig-farmers. Currently, the epidemiology of the CC398 lineage is becoming more complex. CC398 human-adapted isolates are increasingly being identified in bloodstream infections in humans living in animal-free environments. In addition, CC398 isolates are increasingly responsible for invasive infections in various animals. CC398 isolates that colonize asymptomatic pigs and the isolates that infect humans living in animal-free environments (human-adapted isolates) both lack several clinically important S. aureus-associated virulence factors but differ on the basis of their prophage content. Recent findings have provided insight into the influence of a φMR11-like helper prophage on the ability of CC398 isolates to infect humans. To assess the recent spread of the CC398 lineage to various animal species and to investigate the links between the φMR11-like prophage and the emergence of CC398 isolates infecting animals, we studied 277 isolates causing infections in unrelated animals. The prevalence of CC398 isolates increased significantly between 2007 and 2013 (p < 0.001); 31.8% of the animal isolates harbored the φMR11-like prophage. High-density DNA microarray experiments with 37 representative infected-animal isolates positive for φMR11-like DNA established that most infected-animal isolates carried many genetic elements related to antimicrobial resistance and virulence genes, and a φ3 prophage encoding immune-modulating proteins and associated with animal-to-human jumps. Our findings suggest recent clonal expansion and dissemination of a new subpopulation of CC398 isolates, responsible for invasive infections in various animals, with a considerable potential to colonize and infect humans, probably greater than that of human-adapted CC398 isolates, justifying active surveillance. |
| Databáze: | OpenAIRE |
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