Familial Churg-Strauss Syndrome in Two Sisters
| Autor: | Masami Taniguchi, Sonoko Morita, Emiko Ono, Hiroshi Saito, Takahiro Tsuburai, Yukiyoshi Yanagihara, Chiyako Oshikata, Kazuo Akiyama, Naomi Tsurikisawa |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pathology medicine.medical_specialty Disease Human leukocyte antigen Churg-Strauss Syndrome Critical Care and Intensive Care Medicine medicine.disease_cause Pathogenesis Heredity otorhinolaryngologic diseases medicine Humans Aged P-ANCA business.industry Vascular disease Histocompatibility Testing Siblings Respiratory disease Middle Aged medicine.disease respiratory tract diseases surgical procedures operative Immunology Female Cardiology and Cardiovascular Medicine business Systemic vasculitis |
| Zdroj: | Chest. 131:592-594 |
| ISSN: | 0012-3692 |
| DOI: | 10.1378/chest.06-1208 |
| Popis: | Churg-Strauss syndrome (CSS) is an uncommon systemic vasculitis with an increase in the number of eosinophils in the peripheral blood and tissues. Its pathogenesis is unknown, and there is no evidence that genetic factors influence susceptibility to this disease. We present a case of familial CSS in two sisters with atopic-type bronchial asthma and negative perinuclear anti-neutrophil cytoplasmic antibody results. We investigated the human leukocyte antigen typing of the sisters and their six living siblings but found no evidence for heritability of CSS. To our knowledge, this is the first report of familial CSS. |
| Databáze: | OpenAIRE |
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