Recent Advances in Phenylboronic Acid-Based Gels with Potential for Self-Regulated Drug Delivery
| Autor: | Wang Liyan, Shanshan Xiao, Fei Bi, Guangqing Gai, Bozhong Lin, Haopeng Zhu, Chenyu Wang, Zhao Li |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
gel
Drug media_common.quotation_subject phenylboronic acid Insulin delivery Pharmaceutical Science Nanotechnology Review 02 engineering and technology 010402 general chemistry 01 natural sciences Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound Drug Delivery Systems lcsh:Organic chemistry glucose sensitivity parasitic diseases Drug Discovery Physical and Theoretical Chemistry Phenylboronic acid media_common Glucose sensitivity Chemistry Organic Chemistry 021001 nanoscience & nanotechnology Boronic Acids 0104 chemical sciences diabetes therapy Glucose Chemistry (miscellaneous) drug delivery Self-healing hydrogels Drug delivery Molecular Medicine 0210 nano-technology Drug carrier Gels Boronic acid |
| Zdroj: | Molecules, Vol 24, Iss 6, p 1089 (2019) Molecules |
| ISSN: | 1420-3049 |
| Popis: | Glucose-sensitive drug platforms are highly attractive in the field of self-regulated drug delivery. Drug carriers based on boronic acid (BA), especially phenylboronic acid (PBA), have been designed for glucose-sensitive self-regulated insulin delivery. The PBA-functionalized gels have attracted more interest in recent years. The cross-linked three-dimensional (3D) structure endows the glucose-sensitive gels with great physicochemical properties. The PBA-based platforms with cross-linked structures have found promising applications in self-regulated drug delivery systems. This article summarizes some recent attempts at the developments of PBA-mediated glucose-sensitive gels for self-regulated drug delivery. The PBA-based glucose-sensitive gels, including hydrogels, microgels, and nanogels, are expected to significantly promote the development of smart self-regulated drug delivery systems for diabetes therapy. |
| Databáze: | OpenAIRE |
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