Decreased serum levels of thrombospondin‐1 in female depressed patients
| Autor: | Wataru Omori, Chiyo Shibasaki, Naoto Kajitani, Minoru Takebayashi, Mami Okada-Tsuchioka, Kei Itagaki |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
thrombospondin‐1
Adult Male endocrine system medicine.medical_specialty medicine.medical_treatment behavioral disciplines and activities Gastroenterology electroconvulsive therapy Thrombospondin 1 Sex Factors Electroconvulsive therapy immune system diseases Internal medicine Outcome Assessment Health Care mental disorders medicine Humans Hippocampus (mythology) Pharmacology (medical) Depression (differential diagnoses) Aged Pharmacology Depressive Disorder Major business.industry virus diseases Hamilton Rating Scale for Depression Original Articles Middle Aged medicine.disease Psychiatry and Mental health Clinical Psychology depression Major depressive disorder Original Article Female female‐specific business serum |
| Zdroj: | Neuropsychopharmacology Reports |
| ISSN: | 2574-173X |
| Popis: | Aim Thrombospondin‐1 (TSP‐1) is an astrocyte‐derived synaptogenesis‐related factor. It was previously reported to be increased by chronic treatment of electroconvulsive seizure, a model of electroconvulsive therapy (ECT), in rat hippocampus. The aim of this study was to examine whether serum levels of TSP‐1 are associated with depression and ECT. Methods Serum TSP‐1 levels of major depressive disorder (MDD) patients (n = 36) and age‐ and gender‐matched healthy controls (n = 36) were measured by TSP‐1 ELISA. MDD patients were diagnosed according to the Diagnostics and Statistical Manual of Mental Disorders‐IV‐TR and underwent ECT. MDD patients were also analyzed for serum TSP‐1 levels pre‐ and post‐ECT. Evaluation of symptoms was obtained using the Hamilton Rating Scale for Depression. Results Serum TSP‐1 levels showed significant decreases specific to female MDD patients. However, TSP‐1 did not change pre‐ and post‐ECT, did not correlate with symptoms, nor was not affected by the dose of antidepressants. Conclusion Serum TSP‐1 is a possible female‐specific factor that reflects depressive trait, but not state. The aim of this study was to examine whether serum levels of TSP‐1 are associated with depression and ECT. As a result, serum TSP‐1 levels showed significant decreases specific to female depressed patients. However, TSP‐1 did not change pre‐ and post‐ECT. In conclusion, serum TSP‐1 is a possible female‐specific factor that reflects depressive trait, but not state. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text