Higher white matter hyperintensity lesion load is associated with reduced long-range functional connectivity
| Autor: | Iris Lettow, Felix Fischer, Fanny Quandt, Götz Thomalla, Marlene Heinze, Maximilian Schulz, Bastian Cheng, Benedikt M. Frey, Focko L. Higgen, Christian Gerloff, Julian Schröder, Simon S Kessner |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
microangiopathy Electroencephalography Audiology 03 medical and health sciences 0302 clinical medicine Neuroimaging medicine Dementia EEG Cognitive decline 030304 developmental biology 0303 health sciences medicine.diagnostic_test AcademicSubjects/SCI01870 cerebral small vessel disease business.industry leukoaraiosis General Engineering Leukoaraiosis medicine.disease Executive functions Hyperintensity Frontal lobe imaginary coherence Original Article AcademicSubjects/MED00310 business 030217 neurology & neurosurgery |
| Zdroj: | Brain Communications |
| ISSN: | 2632-1297 |
| DOI: | 10.1093/braincomms/fcaa111 |
| Popis: | Cerebral small vessel disease is a common disease in the older population and is recognized as a major risk factor for cognitive decline and stroke. Small vessel disease is considered a global brain disease impacting the integrity of neuronal networks resulting in disturbances of structural and functional connectivity. A core feature of cerebral small vessel disease commonly present on neuroimaging is white matter hyperintensities. We studied high-resolution resting-state EEG, leveraging source reconstruction methods, in 35 participants with varying degree of white matter hyperintensities without clinically evident cognitive impairment in an observational study. In patients with increasing white matter lesion load, global theta power was increased independently of age. Whole-brain functional connectivity revealed a disrupted network confined to the alpha band in participants with higher white matter hyperintensities lesion load. The decrease of functional connectivity was evident in long-range connections, mostly originating or terminating in the frontal lobe. Cognitive testing revealed no global cognitive impairment; however, some participants revealed deficits of executive functions that were related to larger white matter hyperintensities lesion load. In summary, participants without clinical signs of mild cognitive impairment or dementia showed oscillatory changes that were significantly related to white matter lesion load. Hence, oscillatory neuronal network changes due to white matter lesions might act as biomarker prior to clinically relevant behavioural impairment. In patients with higher white matter hyperintensity lesion load, global theta power, measured with EEG, was increased independently of age. Whole-brain functional connectivity revealed a disrupted network confined to the alpha band. Decreased functional connectivity affected long-range connections, mostly connected to the frontal lobe, and preceded pronounced cognitive impairment. Graphical Abstract Graphical Abstract |
| Databáze: | OpenAIRE |
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