RIFM fragrance ingredient safety assessment, 6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-propionaldehyde, CAS Registry Number 33885-51-7
| Autor: | I. G. Sipes, G. A. Burton, M. Date, I. Lee, J. Romine, H. Moustakas, C. Deodhar, Magnus Bruze, Y. Thakkar, K. Joshi, W. Dekant, G. Sullivan, T. M. Penning, A.M. Api, M. Na, Allison D. Fryer, L. Jones, J. Buschmann, D. C. Liebler, D. Selechnik, Yoshiki Tokura, M. Kumar, M. Lavelle, D. Belsito, G. Ritacco, Maria Lúcia Zaidan Dagli, F. Siddiqi, A. Lapczynski, M. A. Cancellieri, D. Botelho, N. Sadekar, Terry W Schultz |
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| Přispěvatelé: | Publica |
| Rok vydání: | 2021 |
| Předmět: |
Litter (animal)
Litter Size Respiratory System Physiology TOXICOLOGIA AMBIENTAL Cosmetics Toxicology Risk Assessment chemistry.chemical_compound Pregnancy Lactation Toxicity Tests medicine Animals Humans Registries Areola Skin Aldehydes No-Observed-Adverse-Effect Level business.industry Dermatitis Photoallergic Mutagenicity Tests Anogenital distance Academies and Institutes Pregnancy Outcome Household Products Propionaldehyde General Medicine Environmental Exposure Fragrance ingredient Perfume medicine.anatomical_structure chemistry Odorants Gestation Female Safety business Sex ratio Food Science Dermatitis Phototoxic |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1873-6351 |
| Popis: | No treatment-related effects at the low and mid doses were observed in gestation, viability and lactation indices, duration of gestation, parturition, sex ratio, maternal care, litter size, and early postnatal pup development consisting of mortality, clinical signs, anogenital distance, areola/nipple retention, T4 thyroid hormone levels, or macroscopic examination. However, the number of litters (N = 5) at the high dose was considered too low for toxicological evaluation. Thus, based on insufficient data at 120 mg/kg/day, the NOAEL for this study was considered to be 60 mg/kg/day (RIFM, 2020d). |
| Databáze: | OpenAIRE |
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