In Silico Study of Plant Polyphenols' Interactions with VP24–Ebola Virus Matrix Protein
| Autor: | Miha Lukšič, Helena Volk, Črtomir Podlipnik, Sebastian Pleško |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Ebolavirus
KPNA5 Ebola virus Chemistry Viral protein In silico viruses food and beverages Alpha Karyopherins molecular docking Epigallocatechin gallate medicine.disease_cause Small molecule lcsh:Chemistry chemistry.chemical_compound Protein structure STAT1 Biochemistry lcsh:QD1-999 medicine General Earth and Planetary Sciences plant polyphenols General Environmental Science VP24 |
| Zdroj: | Acta Chimica Slovenica, Vol 62, Iss 3, Pp 555-564 (2015) |
| ISSN: | 1580-3155 1318-0207 |
| Popis: | The Zaire Ebola viral protein VP24 selectively inhibits nuclear import of STAT1 and as such blocks interferon-induced antiviral responses vital for cell's emergency. Inhibition of VP24 with small molecule inhibitor may neutralize the threatening action of Ebola virus. We performed molecular docking of compounds from a selected small library of plant polyphenols on to VP24. Our research shows that 1,2,3,6-tetragalloyl glucose, epigallocatechin gallate, chlorogenic acic, oleuropein and miquelianin represent promising leads for further studies. |
| Databáze: | OpenAIRE |
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