Autophagy-Dependent Apoptosis Induced by Apoferritin–Cu(II) Nanoparticles in Multidrug-Resistant Colon Cancer Cells
| Autor: | Johannes Karges, Fangmian Wei, Hui Chao, Ying Zhou, Mingwei Lin, Liang-Nian Ji, Jinchao Shen, Kai Xiong, Yu Chen, Jun-Feng Kou, Ke-Jie Du |
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| Rok vydání: | 2021 |
| Předmět: |
Cell Membrane Permeability
Materials science Colorectal cancer Autophagic Cell Death Drug Compounding Cell Antineoplastic Agents Nanocapsules Coordination Complexes Cell Line Tumor Autophagy medicine Animals Humans General Materials Science Cytotoxicity Mice Inbred BALB C Cancer Neoplasms Experimental medicine.disease Drug Resistance Multiple Drug Liberation medicine.anatomical_structure Drug Resistance Neoplasm Apoptosis Apoferritins Colonic Neoplasms Cancer research Female Nanocarriers Copper Conjugate |
| Zdroj: | ACS Applied Materials & Interfaces. 13:38959-38968 |
| ISSN: | 1944-8252 1944-8244 |
| Popis: | Chemotherapy continues to be the most commonly applied strategy for cancer. Despite the impressive clinical success obtained with several drugs, increasing numbers of (multi)drug-resistant tumors are reported. To overcome this shortcoming, novel drug candidates and delivery systems are urgently needed. Herein, a therapeutic copper polypyridine complex encapsulated in natural nanocarrier apoferritin is reported. The generated nanoparticles showed higher cytotoxicity toward various (drug-resistant) cancer cell lines than noncancerous cells. The study of the mechanism revealed that the compound triggers cell autophagy-dependent apoptosis. Promisingly, upon injection of the nanodrug conjugate into the bloodstream of a mouse model bearing a multidrug-resistant colon tumor, a strong tumor growth inhibition effect was observed. To date, this is the first study describing the encapsulation of a copper complex in apoferritin that acts by autophagy-dependent apoptosis. |
| Databáze: | OpenAIRE |
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