Tissue factor pathway inhibitor 2 as a serum marker for diagnosing asymptomatic venous thromboembolism in patients with epithelial ovarian cancer and positive D‑dimer results

Autor:	Ryuta, Miyake, Yuki, Yamada, Shoichiro, Yamanaka, Ryuji, Kawaguchi, Norihisa, Ootake, Shohei, Myoba, Hiroshi, Kobayashi
Rok vydání:	2021
Předmět:	Cancer Research Oncology cardiovascular diseases Articles equipment and supplies
Zdroj:	Mol Clin Oncol
ISSN:	2049-9469 2049-9450
DOI:	10.3892/mco.2021.2479
Popis:	Tissue factor pathway inhibitor 2 (TFPI2) is a serodiagnostic marker for epithelial ovarian cancer (EOC) and is the primary inhibitor of the extrinsic coagulation pathway. The present study assessed the diagnostic performance of TFPI2 for detecting venous thromboembolism (VTE) in patients with EOC and positive D-dimer results (>1.0 µg/ml). First, the clinical data of 81 patients with EOC admitted to Nara Medical University Hospital between January 2008 and December 2015 were collected. Also, 25 patients with VTE and 56 patients without VTE were included. Receiver-operating characteristic (ROC) curve analyses were performed to determine the diagnostic efficacy of TFPI2 in discriminating patients with VTE from those without VTE. Serum TFPI2 levels in patients with VTE were significantly higher than in non-VTE patients (median, 472.2 vs. 279.1 pg/ml, P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f59cec162c3a3bdd7f116f718dda94 https://doi.org/10.3892/mco.2021.2479 Zobrazit plný text záznamu