Biomarkers in Non-Complicated Pregnancy: Insights About Serum Myeloperoxidase and Ultrasensitive C-Reactive Protein
| Autor: | Luciana Maria Borba, Danielle C. Kalva-Borato, Margarete Aparecida Salina Maciel, Gisele Chibinski Parabocz, Josilaine Tonin Ribas, José Carlos Rebuglio Vellosa, Fábio André dos Santos |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Endocrinology Diabetes and Metabolism Physiology 030209 endocrinology & metabolism Inflammation Systemic inflammation 03 medical and health sciences 0302 clinical medicine Endocrinology Pregnancy Internal Medicine medicine Humans Peroxidase biology business.industry Monocyte C-reactive protein General Medicine medicine.disease 030104 developmental biology medicine.anatomical_structure C-Reactive Protein Myeloperoxidase biology.protein Gestation Biomarker (medicine) Female Pregnancy Trimesters medicine.symptom business |
| Zdroj: | Experimental and clinical endocrinologydiabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 127(9) |
| ISSN: | 1439-3646 |
| Popis: | Introduction Pregnancy is characterized by increased innate immune response, with low-grade systemic inflammation. The specific role of MPO during normal pregnancy remains not well understood. Therefore, the aim of this study was to evaluate plasma levels of MPO, hs-CRP, total leukocyte, absolute neutrophil and monocyte counts, in all trimesters of normal human pregnancy compared with non-pregnant controls. In addition, possible fluctuations of MPO according to different inflammatory conditions in the normal gestation were studied. Materials and methods Case-control study (n=84) developed with 63 normal pregnant women and 21 healthy non-pregnant women. Total leukocyte, absolute neutrophils and absolute monocytes count, hs-CRP and MPO were measured in non-pregnant women and normal human pregnancy. They were evaluated according to the 3 trimesters of pregnancy and systemic low grade inflammatory status, which was identified through increased hs-CRP levels. Results MPO levels in the normal pregnant women were not elevated in every 3 trimesters of pregnancy (P=0.456) or in systemic inflammation (P=0.446). The hs-CRP levels, total leukocyte, absolute neutrophil and monocyte counts are present in higher concentrations in normal pregnant women in relation to non-pregnant women. Conclusions The MPO did not show fluctuations in plasma levels during the 3 trimesters of gestation or in relation to different inflammation conditions. Considering MPO and hs-CRP levels are changed in high cardiovascular risk conditions and MPO levels (unlike hs-CRP) didn’t increase during non complicated pregnancy, MPO could be a better biomarker than hs-CRP to monitor these patients. |
| Databáze: | OpenAIRE |
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