Cdc20 inhibitor apcin inhibits the growth and invasion of osteosarcoma cells
Autor: | Yuming Wang, Benyuan Zhang, Shang Guanning, Gao Yuan |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Cyclin-Dependent Kinase Inhibitor p21 Cancer Research Cdc20 Proteins Cell Apoptosis CDC20 Diamines 03 medical and health sciences 0302 clinical medicine Cell Line Tumor medicine Humans Cell Proliferation Osteosarcoma biology Bcl-2-Like Protein 11 Cell growth Chemistry General Medicine Cell cycle medicine.disease Ubiquitin ligase Up-Regulation 030104 developmental biology medicine.anatomical_structure Oncology Tumor progression 030220 oncology & carcinogenesis biology.protein Cancer research Disease Progression Carbamates Anaphase-promoting complex |
Zdroj: | Oncology reports. 40(2) |
ISSN: | 1791-2431 |
Popis: | Osteosarcoma (OS) is the most common primary malignant bone tumor worldwide, primarily affecting children and adolescents. The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that is activated by its co‑activator Cdc20 during the metaphase‑anaphase transition. Apcin is a novel cell‑permeable molecule that blocks the interaction between APC/C and Cdc20. Cdc20 overexpression has been reported in various malignancies and plays an oncogenic role in tumorigenesis and tumor progression. In the present study, the antitumor properties of apcin, an inhibitor of Cdc20, was investigated in OS cell lines. In addition, the possible molecular target by which apcin mediates cell death was explored. Apcin was demonstrated to inhibit OS cell growth and induce significant apoptosis. The invasion and mobile abilities of OS cells were also markedly suppressed by apcin treatment. Furthermore, Bim and p21 were upregulated in OS cells following apcin treatment. The results of the present study indicated that apcin may have therapeutic potential as a treatment for OS and that Cdc20 may be a promising molecular target for chemotherapy. |
Databáze: | OpenAIRE |
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