Combining NHC-Cu and Brønsted Base Catalysis: Enantioselective Allylic Substitution/Conjugate Additions with Alkynylaluminum Reagents and Stereospecific Isomerization of the Products to Trisubstituted Allenes

Autor:	Fredrik Haeffner, Jennifer A. Dabrowski, Amir H. Hoveyda
Rok vydání:	2013
Předmět:	chemistry.chemical_classification Substitution reaction Allylic rearrangement Stereochemistry Allene Enantioselective synthesis Allyl compound Alkyne General Chemistry General Medicine Medicinal chemistry Catalysis chemistry.chemical_compound chemistry Nucleophile Carbene
Zdroj:	Angewandte Chemie. 125:7848-7853
ISSN:	0044-8249
Popis:	All-catalytic route to trisubstituted allenes: The first examples of catalytic enantioselective allylic substitution reactions that involve alkyne-based nucleophiles and lead to products having tertiary stereogenic centers are followed by an exceptionally stereospecific amine-catalyzed isomerization to trisubstituted allenes (see picture; NHC = N-heterocyclic carbene).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f097e46bd59849d8031833c42329cc https://doi.org/10.1002/ange.201303501 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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